Publications by authors named "Rebeca S Klimek"
Immunol Cell Biol
November 2020
Article Synopsis
- Obesity triggers inflammation in the body by activating specific immune cells called adipose tissue macrophages (ATMs), shifting their types from beneficial to harmful.
- In healthy individuals, ATMs in fat tissue generally promote tissue health (M2 type), but in obese people, there’s an increase in inflammatory ATMs (M1 type), especially in subcutaneous fat (SAT).
- The study identified key markers for these macrophage types and found that while the overall count of beneficial ATMs increased in SAT of obese individuals, changes in visceral fat (VAT) were more complex, with a mix of both harmful and helpful macrophages present.
