Poverty and survival from COVID-19 in Mexico.

Background: Recent evidence points to the relevance of poverty and inequality as factors affecting the spread and mortality of the COVID-19 pandemic in Latin America. This study aimed to determine whether COVID-19 patients living in Mexican municipalities with high levels of poverty have a lower survival compared with those living in municipalities with low levels.

Methods: Retrospective cohort study.

Cannabis and the exocannabinoid and endocannabinoid systems. Their use and controversies.

Cannabis (marijuana) is one of the most consumed psychoactive substances in the world. The term marijuana is of Mexican origin. The primary cannabinoids that have been studied to date include cannabidiol and delta-9-tetrahydrocannabinol, which is responsible for most cannabis physical and psychotropic effects.

Cannabis y los sistemas exocannabinoide y endocannabinoide. Su uso y controversias.

Cannabis (marijuana) is one of the most consumed psychoactive substances in the world. The term marijuana is of Mexican origin. The primary cannabinoids that have been studied to date include cannabidiol and delta-9-tetrahydrocannabinol, which is responsible for most cannabis physical and psychotropic effects.

[Association between neuropathy and peripheral vascular insufficiency in patients with diabetes mellitus type 2].

Introduction: Diabetes mellitus (DM) can present complications of neuropathy and peripheral arterial disease with high risk for developing foot ulcers and consequent amputations.

Objective: To identify the association between peripheral vascular disease, and neuropathy in type 2 Diabetes mellitus patients from the Hospital General de Zona No. 1 IMSS in Colima, Mexico.

A280V polymorphism in the histamine H3 receptor as a risk factor for migraine.

Background And Aims: Activation of histamine H3 receptors blocks the release of peptides responsible for headache. Our objective was to investigate the association between the genotypes of A280V polymorphism in the H3 receptor and migraine risk.

Methods: We evaluated the frequency of the genotypes of A280V, polymorphism A280V and allelic variants of H3 receptor in 147 migraine patients and 186 healthy controls using a PCR-RLFP method.

[Clinical study of patients with cranial trauma].

Objective: To identify clinical characteristics and prognosis in patients with cranial trauma.

Methods: A longitudinal design was used to study 302 patients between the years 2003 and 2006. Variables were mechanism and type of lesion, localization, clinical condition, Glasgow Coma Scale and prognosis.

[The frequency of risk factors associated with obesity and being overweight in university students from Colima, Mexico].

Objective: Determining risk factor frequency regarding obesity and being overweight in university students.

Methods: A cross-sectional analytic study was carried out on 821 students from the University of Colima. Some variables analysed were age, gender, alcoholism, smoking and weight-control drug use.

Prolonged cold ischemia: risk factor for acute rejection in renal grafting of cadaveric kidney transplantation.

Background: Exposure of renal grafting to prolonged cold ischemia time (CIT) and the association with acute rejection (AR) are known. However, there is no evidence in Mexico about this topic. Thus, the objective of this study was to evaluate prolonged CIT as a risk factor for AR in renal grafting of cadaveric kidney transplantation in a Mexican population.

[Antibiotic therapy frequency in hospitalised patients and associated risk factors].

Objective: Determining antimicrobial indication and frequency of use in hospitalised patients.

Materials And Methods: Date and place of work: May 1st to June 30th 2006, Colima, Mexico. An analytical cross-sectional study was carried out; it involved 400 patients from both sexes hospitalised in different second level hospital departments.

[New therapeutic alternatives in migraine prophylaxis using histamine H3 receptor agonists].

Background: Subcutaneous histamine at low concentrations interacts with H3-receptors and may constitute a new therapeutic drug in migraine prophylaxis. It acts by limiting the excessive inflammatory response involved in migraine pathophysiology.

Objective: Describe the results of a 15-year trial administering histamine at low concentrations.

[Frequency of intestinal helminthiasis and its association with iron deficiency and malnutrition in children from western Mexico].

Objective: To determine intestinal helminthiasis frequency and its association with malnutrition and iron deficiency.

Material And Methods: An analytical cross-over study was carried out on children in the municipality of Comala, Colima, Mexico. Coproparasitoscopic exams in series of three using the Kato-Katz technique were performed in all children.

[Longitudinal study of three families with familial Parkinson's disease].

Background: Familial Parkinson's is a variant of Parkinson's disease (PD) transmitted generationally with an early onset.

Objective: Describe the clinical disease characteristics and its 18 year evolution among families in Colima presenting familial PD.

Materials And Methods: We determined disease diagnosis, evolution and hereditary pattern.

Blink reflex, H-reflex and nerve-conduction alterations in leprosy patients.

Peripheral nerve lesions are the most important cause of disability in leprosy patients. Electrophysiological studies are used in the diagnosis and prognosis of neuropathy. Nerve conduction is the most frequently used electrophysiological test method to detect neuropathy, although it evaluates only a part of the peripheral nervous system.

Nalpha-methyl histamine safety and efficacy in migraine prophylaxis: phase III study.

Background: The histamine catabolite, Nalpha-methylhistamine, possesses a selective affinity for H3 receptors. For this reason, we considered evaluating the efficacy of this histaminergic H3 agonist in migraine prophylactic treatment.

Objective: To study the therapeutic potential of the subcutaneous administration of Nalpha-methylhistamine in migraine prophylaxis, in a Phase III clinical pharmacological study.

[Assessment of a postural reference frame as a diagnostic test for lumbar lordotic posture].

Introduction: Studying lumbar lordosis (LL) in large patient populations is not a practical approach due to the technical limitations of the gold standard.

Objective: Determine the specificity of a postural reference frame (PRF) in the diagnosis of LL.

Methods: A PRF (wooden frame using strings as a reference for measuring the distance between lumbar curvature and the glutei) was used as a diagnostic test to asses LL.

F-wave and H-reflex alterations in recently diagnosed diabetic patients.

Objective: To explore the frequency of F-wave and H-reflex alterations in recently diagnosed type 2 diabetes mellitus patients and to determine if the alterations are dependent on the levels of glycemia.

Methods: A cross-sectional study was carried out on 50 asymptomatic patients, with a mean age of 45.4 +/- 9.

[Causes of non-use of postpartum contraceptive method among adolescent mothers].

Objective: To determine the causes of non postpartum contraceptive use among adolescent mothers.

Patients And Methods: We conducted a cross-section descriptive study. We included women who asked for attention of an obstetric event in 2002, we identified those were in immediate postpartum period, and we selected those that did not began a birth-control method.

[Physical abuse of women].

Objective: Our aim was determine prevalence of intrafamily violence of the type physical-abuse, toward female claimants aged 18 years and older at the HGZ MF No. 1 in Colima.

Material And Method: A transversal study was conducted in 288 females aged 18 years and older who were seen at the Family Medicine Unit for external consultation.

[Migraine. Review of physiopathogeny and future alternative therapy].

This work examines recent discoveries in physiopathogenesis, focusing on the combination of sequential events involved in migraine origin. Recent facts concerning active intestinal peptide, substance P, histamine, HI and H3 receptors, and H3-receptor agonists, all neuromodulators having an intimate relations ship with migraine were examined. Present-day recommended treatment, with an efficacy of barely 70%, and reasons for its poor performance were described.

[Hyperhomocysteinemia in acute cerebral infarction].

Antecedents: Hyperhomocysteinemia has recently been recognized as contributing directly or associatively to the arteriosclerotic process in cerebral infarction.

Objective: To determine plasmatic homocysteine levels in with patients with acute cerebral infarction and to seek an association between clinical sub-types of cerebral lesion and homocysteine levels and risk factors present.

Materials And Methods: A descriptive study was carried out on patients diagnosed with acute cerebral infarction.

Nalpha-methylhistamine safety and efficacy in migraine prophylaxis: phase I and phase II studies.

Objective: To study the therapeutic potential of the subcutaneous administration of Nalpha-methylhistamine in migraine prophylaxis.

Background: The histamine catabolite, Nalpha-methylhistamine, possesses a selective affinity for H3 receptors. We consequently considered it viable to conduct a clinical pharmacological study to evaluate the safety and efficacy of this histaminergic H3 agonist in migraine prophylactic treatment, which specifically may inhibit the neurogenic edema response involved in migraine pathophysiology.

[Cyanoacrylate compared with traditional surgery in tension-free incision closure].

Objective: To investigate the efficiency of cyanoacrylate in closing tension-free incisions in out-patient surgery compared with traditional suturing methods.

Patient And Methods: A single, blind, clinical study was carried out on 60 patients divided into two groups. Group 1 (n = 30) received one or two drops of cyanoacrylate directly on the incision.

[White-coat hypertension and risk factors in recently diagnosed hypertensive patients].

Objective: To determine the frequency of white-coat hypertension (WCH) and associated risk factors in recently diagnosed hypertensive patients.

Material And Methods: A cross-sectional study was carried out from January 1997 to December 1998. The reference population consisted of 195 patients presenting with systemic arterial hypertension (SAH) of less than 1-month evolution and receiving no medical treatment.