Publications by authors named "Rebeca M Santamaria"
Article Synopsis
- Bovine babesiosis is a significant disease in cattle caused by a protozoan, and researchers aim to understand the differences between an attenuated vaccine strain and a virulent strain by examining gene expression.
- A study was conducted where cattle received either the attenuated or virulent strain, and RNA was extracted for comprehensive transcriptomic analysis, revealing over 500 differentially expressed genes.
- The findings highlighted both common and distinct biological processes between the strains, providing valuable insights into the mechanisms of attenuation and pathogenicity, which could inform future vaccine development.
The objective of this study was to instrument a serological assay for the epidemiological diagnosis of bovine babesiosis in Mexico, using the Babesia bigemina recombinant protein RAP-1 (rRAP-1α) as antigen. rRAP-1α, r12d3 and rGP45 were the three recombinant antigens initially tested. Based on the highest titres obtained in the indirect ELISA (iELISA) with the positive control serum, using similar antigen concentrations, rRAP-1α was selected for further use.
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