Impact of HLA Alloimmunization in Gene-Modified Autologous Stem Cell Transplant For Transfusion-Dependent Thalassemia.

We report our single center experience demonstrating that HLA Class I alloimmunization predicts longer time to platelet engraftment, increased bleeding complications and higher transfusion requirements in patients undergoing gene-modified hematopoietic stem cell transplant for transfusion-dependent beta thalassemia.

Serotonergic Antidepressant Use and Risk of Clinically Significant Bleeding in Thrombocytopenic Hematologic Malignancy Patients.

Background: Serotonin reuptake inhibitor (SRI) antidepressants have known antiplatelet properties. Patients with hematologic malignancies (HMs) are at an increased risk of bleeding complications due to their malignancy and treatment-induced thrombocytopenia.

Objective: The purpose of this study was to evaluate the risk of clinically significant bleeding (CSB) in patients with HM and thrombocytopenia who are prescribed SRIs.

Dual-Baseline Search for Active-to-Sterile Neutrino Oscillations in NOvA.

We report a search for neutrino oscillations to sterile neutrinos under a model with three active and one sterile neutrinos (3+1 model). This analysis uses the NOvA detectors exposed to the NuMI beam, running in neutrino mode. The data exposure, 13.

South Dakota State University Extension's two-year beefSD program has high impact on beginning beef cattle producers.

The value of Extension programming is the generation of short (knowledge gain), medium (behavior change), and long (condition improvement) term outcomes or impact for clientele. Evaluating impact is a critical step in Extension programming. Effective evaluation can be used to measure outcomes, adapt and improve curricula of ongoing programs, and document public value gained from Extension funding.

The conceptual structure of human relationships across modern and historical cultures.

A defining characteristic of social complexity in Homo sapiens is the diversity of our relationships. We build connections of various types in our families, workplaces, neighbourhoods and online communities. How do we make sense of such complex systems of human relationships? The basic organization of relationships has long been studied in the social sciences, but no consensus has been reached.

Navigating uncertainty in low back pain care through an ethic of openness: Learnings from a post-critical analysis.

Theoretical and practical guidance on how to navigate uncertainties in healthcare are scarce. Here, we draw from Gibson's ethic of openness to explore clinicians' experiences navigating uncertainty with individuals who experience low back pain (LBP) and provide guidance on avenues for navigating uncertainty in LBP and healthcare more broadly. Our analysis suggests that clinicians practice within different philosophical commitments when providing care for individuals with LBP, with some of them aligning with a (post)positivist approach with pre-determined endpoints and others an ethic of openness, with no fixed endpoints and consideration of multiple options and perspectives.

Real-Time Mapping of Polymer Film Thickness Using Near-Infrared Hyperspectral Imaging.

A new method based on near-infrared (NIR) hyperspectral imaging (HSI) has been developed for online polymer film thickness mapping. Traditional online methods, including X-ray, capacitance, and physical gauging (micrometers), can only determine film thickness for a point with each measurement. The NIR-HIS method allows the determination of film thickness for a line based on each image, thus enabling true real-time two-dimensional (2D) mapping of film thickness as the film translates in front of the instrument.

Clinical significance of sleepiness: an American Academy of Sleep Medicine position statement.

Alertness is a necessity for well-being and performance, and sleepiness is associated with cognitive and functional impairments that can have a negative impact on performance, health, mood, safety, and quality of life. In severe cases, sleepiness can lead to debilitation, injury, or death. Sleepiness is a marker of insufficient sleep and is the major patient-reported symptom associated with disorders of sleep and wakefulness such as narcolepsy and obstructive sleep apnea.

The role of friendship maintenance over communication technologies in freshmen's social adjustment to college.

Studies show that friendships help undergraduates navigate the transition to college, but it is unclear how technology use impacts the maintenance of friendships and students' subsequent adjustment. This study fills this gap by examining how maintenance over communication technologies with pre-college and in-college friends is associated with freshmen's social adjustment to college, via two psychological processes: social support and belongingness. 194 college freshmen completed online surveys.

Pattern separation and pattern completion in early childhood.

Pattern separation, or distinguishing similar experiences from one another, and pattern completion, in which components of an experience prompt retrieval or forgetting of an event pattern as a unit, are essential components of episodic memory. However, these two components are sometimes described as opposite ends of a continuum and sometimes described as independent processes. Here, we examined the relations between the two processes for the same events in children between 4 and 7 y.

Integrated Evidence Planning for Enhancing Patient Care: Harnessing the Power of Real-World Evidence.

Real-World Evidence (RWE), as an important pillar of Integrated Evidence Plans (IEP), offers a promising tool to address numerous hurdles impeding patients to receive timely and adequate treatments.

Data retention in awake infant fMRI: Lessons from more than 750 scanning sessions.

Functional magnetic resonance imaging (fMRI) in awake infants has the potential to reveal how the early developing brain gives rise to cognition and behavior. However, awake infant fMRI poses significant methodological challenges that have hampered wider adoption. The present work takes stock after the collection of a substantial amount of awake infant fMRI data across multiple studies from two labs at different institutions.

: welcoming a new year in biophysics.

This Editorial introduces the contents of Volume 17, Issue 1 of , the official journal of the International Union for Pure and Applied Biophysics (IUPAB). A major highlight of the Issue is the announcement of the winner of the 2025 Michéle Auger Award for Young Scientists' Independent Research. The broad scope of the articles in the Issue and the geographically widespread locations of the contributing authors of the reviews in the Issue mirror the goals of IUPAB, namely to organize worldwide advancements, co-operation, communication, and education in biophysics.

Widespread Multimorbidity in a Cohort of Aging, Radiation-exposed Rhesus Macaques.

Delayed effects of acute radiation exposure (DEARE) and radiation late effects are a suite of conditions that become apparent months to years after initial exposure to radiation in both humans and non-human primates. Many of these disorders, including cardiac complications, insulin resistance, bone loss, hypertension, and others, are also more common among aging cohorts independent of radiation exposure. This study characterized disease incidence, age of onset, and multimorbidity for 20 common, chronic diseases in 226 irradiated and 51 control rhesus macaques (Macaca mulatta) from the Wake Forest Non-Human Primate Radiation Late Effects Cohort (RLEC) to identify the excess risk of chronic disease caused by radiation-induced tissue damage.

Radiation-induced Brain Injury and the Radiation Late Effects Cohort (RLEC) of Rhesus Macaques (Macaca mulatta).

In the event of a nuclear accident or attack, thousands of people could receive high doses of total-body irradiation (TBI). Although retrospective analyses of atomic bomb and nuclear disaster survivors have been conducted, the long-term outcomes on the brain and cognitive function are conflicting. Radiation-induced brain injury (RIBI) is characterized by inflammation, vascular injury, deficits in neuronal function, and white matter (WM) injury, but the molecular mechanisms by which this occurs remain unknown.

Predictors of Long-Term Survival in Patients with Idiopathic Pulmonary Fibrosis: Data from the IPF-PRO Registry.

Purpose: We used data from the IPF-PRO Registry of patients with idiopathic pulmonary fibrosis (IPF) to identify characteristics that predicted survival for a further > 5 years.

Methods: Participants had IPF that was diagnosed or confirmed at the enrolling center in the previous 6 months. Patients were followed prospectively.

Measuring and interpreting individual differences in fetal, infant, and toddler neurodevelopment.

As scientists interested in fetal, infant, and toddler (FIT) neurodevelopment, our research questions often focus on how individual children differ in their neurodevelopment and the predictive value of those individual differences for long-term neural and behavioral outcomes. Measuring and interpreting individual differences in neurodevelopment can present challenges: Is there a "standard" way for the human brain to develop? How do the semantic, practical, or theoretical constraints that we place on studying "development" influence how we measure and interpret individual differences? While it is important to consider these questions across the lifespan, they are particularly relevant for conducting and interpreting research on individual differences in fetal, infant, and toddler neurodevelopment due to the rapid, profound, and heterogeneous changes happening during this period, which may be predictive of long-term outcomes. This article, therefore, has three goals: 1) to provide an overview about how individual differences in neurodevelopment are studied in the field of developmental cognitive neuroscience, 2) to identify challenges and considerations when studying individual differences in neurodevelopment, and 3) to discuss potential implications and solutions moving forward.

The Long-term Effects of Acute Total-Body Irradiation on Pre-irradiation Measles-vaccine-induced Immunological Memory.

Acute total-body irradiation (TBI) leads to transient dose-dependent lymphopenia. While lymphocyte numbers gradually recover, there remain subtle but long-lasting changes to B and T cell populations years after radiation exposure. The degree to which immunological memory is retained after TBI is unknown; however, it is conceivable that vaccine-induced protective immunity is jeopardized.

A Quality Improvement Initiative to Reduce Opioid Use Following Routine Thyroid and Parathyroid Surgery.

Objective: Evaluate the postoperative pain management of patients at a single institution following routine thyroid and parathyroid surgery and compare patient opioid use before and after a practice wide quality improvement change.

Study Design: Retrospective chart review with prospective survey administration.

Setting: University of New Mexico Hospital.

Gender categorization and memory in transgender and cisgender people.

Gender categorization is central to everyday life. Discussions about gender have traditionally focused on , or gender categories to which a person might have an internal sense of belonging (e.g.

Integrating epidemiology and genomics data to estimate the prevalence of acquired cysteine drug targets in the U.S. cancer patient population.

Reliable estimates for the number of cancer patients with a specific mutation can help quantify the size of the population that could potentially benefit from a targeted therapy. We adapt our previously developed approach for estimating gene-level mutation abundances to estimate mutation-specific (e.g.

Multiple meningiomas of different variants in a single patient: illustrative cases.

Background: Meningiomas are the most common primary intracranial tumors, accounting for approximately one-third of all primary brain neoplasms, typically characterized by a single histological variant. Multiple meningiomas are a relatively rare occurrence in a single patient, particularly when exhibiting different histopathological variants.

Observations: The authors present the cases of three patients, each with two separate intracranial meningiomas of different variants.

Deaminase Inhibitor and Casein Hydrolysates Drive Microbial Shifts Favoring Campylobacter jejuni in an In Vitro Poultry Cecal Model.

Aim: The dietary proteins in poultry feeds, including the polypeptide chain size, influence gut microbial composition and function. This study assessed the microbial preference for peptide size using the same protein source in three polypeptide forms.

Methods: We investigated the effects of diphenyliodonium chloride (DIC) on poultry cecal microbiota inoculated with C.