Publications by authors named "Rebbeck T"
Background: Prior to COVID-19, little was known about how risks associated with such a pandemic would compete with and influence patient decision making regarding cancer risk reducing medical decision making. We investigated how the pandemic affected preferences for medical risk-reducing strategies among women at elevated risk of breast or ovarian cancer.
Methods: We conducted a discrete choice experiment.
Purpose: To evaluate the acceptability and feasibility of a consumer co-designed telehealth intervention which aimed to reduce claimant distress by providing pain management strategies, informational and social support to people who had made a compensation claim following road traffic musculoskeletal injury.
Methods: Eleven claimant participants who were at risk of a poor outcome completed the intervention in a one-on-one setting with the same clinician delivering the program across all sessions.They were interviewed about their experience (acceptability and feasibility including the use of telehealth).
Article Synopsis
- Carriers of BRCA1/2 pathogenic variants were studied to determine their risk of developing cancers during childhood, adolescence, and young adulthood (CAYA).
- Analysis of data from over 47,000 individuals revealed that while young women with BRCA1/2 mutations had a significantly increased risk of breast cancer in their 20s, no increased risk was found for other types of CAYA cancers.
- The study concluded that there's little evidence to support routine genetic testing for children of BRCA1/2 carriers or for young cancer patients, as the overall cancer risk appears low aside from breast cancer in young women.
Cancer genetic data from Sub-Saharan African (SSA) are limited. Patients with female breast (fBC), male breast (mBC), and prostate cancer (PC) in Rwanda underwent germline genetic testing and counseling. Demographic and disease-specific information was collected.
View Article and Find Full Text PDFBackground: Rising metastatic prostate cancer incidence has renewed debate regarding benefits of prostate-specific antigen (PSA) screening. Identifying barriers to accessing screening for individuals at high risk of lethal prostate cancer may slow this rise. We examined associations of access barriers with receipt of PSA testing, stratified by sociodemographic factors.
View Article and Find Full Text PDFPurpose: National guidelines recommend next generation sequencing (NGS) of tumors in patients diagnosed with metastatic prostate cancer (mPCa) to identify potential actionable alterations. We sought to describe the spectrum and frequency of alterations in PCa-related genes and pathways, as well as associations with self-identified race/ethnicity, and overall survival in US Veterans.
Patients And Methods: This retrospective cohort study included Non-Hispanic Black (NHB) and Non-Hispanic white (NHW) Veterans with mPCa who obtained NGS through the Veterans Affairs National Precision Oncology Program.
Purpose: Globally, there were 19.3 million new cancer cases and 10 million cancer deaths, with the African continent contributing approximately 1.1 million new cases and over 700,000 deaths to the global cancer burden in 2020.
View Article and Find Full Text PDFTo (1) investigate whether different labels for neck pain after a motor vehicle crash (MVC) influenced recovery expectations and management beliefs, (2) explore reasons for low recovery expectations and greater likelihood for lodging a claim, and (3) explore the moderating effect of neck pain history and sociodemographic characteristics. Online randomized experiment with nested qualitative content analysis. We randomized 2229 participants from the general population (mean age: 46.
View Article and Find Full Text PDFPurpose: Recovering from compensable injuries can be influenced by a variety of factors including the claimant's experience of distress during the claims process. In order to develop cross-scheme, nation-wide strategies to improve claimants' interactions with the compensation system, reduce claimant distress, and improve claimant outcomes, it is important to understand sources of claims-related distress from the perspective of both claimants and clinicians.
Methods: An exploratory qualitative design was undertaken using semi-structured interviews with 13 claimants and 26 clinicians from four injury compensation schemes in five Australian states.
Article Synopsis
- Men of African descent experience the highest rates of prostate cancer, but the genetic factors behind this have not been thoroughly explored.
- Researchers analyzed genetic data from nearly 4,000 prostate cancer cases and over 3,500 controls across several African countries to identify specific genetic associations related to the disease.
- The study found 15 significant genetic associations, including four new ones, highlighting that genetic variation in prostate cancer is influenced by unique African alleles, suggesting that more research in diverse populations is crucial for understanding cancer genetics.
Article Synopsis
- The term 'precancer' describes an early stage of abnormal cell development that diverges from normal tissue due to specific molecular and phenotypic changes, making these cells less reliant on typical growth signals.
- Defining precancer is complex, and while histopathologists can identify cancerous tissues through significant changes, distinguishing precancer from non-cancerous tissues is still a work in progress in both research and clinical settings.
- The text proposes a conceptual framework to better define precancer, focusing on molecular, pathological, clinical, and epidemiological criteria to enhance understanding and potential early interventions.
Article Synopsis
- A study called the THRIVE trial is looking at how exercise can help Hispanic/Latinx and Black cancer patients who are getting chemotherapy and might not be very active.
- The trial includes 45 patients who are split into three groups: one gets supervised exercise at home, another exercises on their own, and the last group does stretching exercises.
- Researchers will check how much exercise the patients do and other health factors before, during, and after the 16-week program to see what works best.
Background: Black men consistently have higher rates of prostate cancer (PCA)- related mortality. Advances in PCA treatment, screening, and hereditary cancer assessment center around germline testing (GT). Of concern is the significant under-engagement of Black males in PCA GT, limiting the benefit of precision therapy and tailored cancer screening despite longstanding awareness of these disparities.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore how well people accepted specialist musculoskeletal care within a new treatment pathway for common conditions like low back pain and knee osteoarthritis.
- Using interviews and quantitative measures, researchers analyzed experiences from 29 participants who were at risk of poor outcomes from the intervention.
- Key findings highlighted that most participants reported satisfaction and positive changes in their physical and mental health, with themes emerging around expectations, the quality of care, and the effectiveness of the care pathway, although some concerns about perceived effectiveness were noted.
Article Synopsis
- The study investigates the experiences of clinicians in Australia who provide care to patients with compensable injuries, highlighting the challenges they face in this stressful environment.* -
- Through interviews with 26 clinicians, it was found that they deal with high patient distress and administrative burdens, leading to feelings of emotional exhaustion in some while others find meaning and purpose in their work.* -
- Positive coping strategies, such as mentoring and continuous education, enhance clinician well-being and improve patient care, stressing the importance of a supportive workplace culture.*
Background: Musculoskeletal injuries can cause distress, and distress is associated with delayed recovery. Numerous interventions have been developed to facilitate recovery from injury, and several systematic reviews evaluate the efficacy of these interventions for reducing psychological distress.
Objectives: This scoping review aims to map the synthesised evidence for the relationship between treatment interventions and distress-related outcomes following acute injury.
Multiple myeloma (MM) is a plasma cell disorder accounting for approximately 10% of hematologic malignancies. There is limited epidemiological evidence regarding the long-term trends and disparities in MM in the US. We conducted a multiple time point cross-sectional study using MM incidence rate data from the Surveillance, Epidemiology, and End Results (SEER) database and mortality data from the CDC Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) Underlying Cause of Death database between 1999 and 2020.
View Article and Find Full Text PDFPurpose: Prostate cancer disproportionately affects men of African descent, yet their representation in tissue-based studies is limited. This multinational, multicenter pilot study aims to establish the groundwork for collaborative research on prostate cancer in sub-Saharan Africa.
Methods: The Men of African Descent and Carcinoma of the Prostate network formed a pathologist working group representing eight institutions in five African countries.
Importance: Prostate-specific antigen (PSA) screening for prostate cancer is controversial but may be associated with benefit for certain high-risk groups.
Objectives: To evaluate associations of county-level PSA screening prevalence with prostate cancer outcomes, as well as variation by sociodemographic and clinical factors.
Design, Setting, And Participants: This cohort study used data from cancer registries based in 8 US states on Hispanic, non-Hispanic Black, and non-Hispanic White men aged 40 to 99 years who received a diagnosis of prostate cancer between January 1, 2000, and December 31, 2015.
Background: In the United States, Black men are at highest risk for being diagnosed with and dying from prostate cancer. Given this disparity, we examined relevant data to establish clinical prostate-specific antigen (PSA) screening guidelines for Black men in the United States.
Methods: A comprehensive literature search identified 1848 unique publications for screening.
Genetic testing and molecular imaging have great promise in the accurate diagnosis and treatment of #prostate #cancer, but only if they can be developed and implemented to achieve equitable benefit for all men.
View Article and Find Full Text PDFCancer prevention is central to efforts to control the burden of cancer. We propose a new terminology framework to help guide these efforts and promote a key equity principle: "equal care for equal risk."
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates participation disparities in clinical trials for acute leukemia at Comprehensive Cancer Centers, focusing on minoritized racial and ethnic groups and identifying whether these inequities arise from access or enrollment issues post-access.
- - Over a period from 2010 to 2019, researchers examined data from 3,698 individuals in Massachusetts, revealing that a significant majority (85.9%) were non-Hispanic White, while groups like Hispanic White and Non-Hispanic Black had notably lower access and enrollment rates.
- - The findings indicate that social factors like socioeconomic status and marital status contribute minimally to enrollment disparities, suggesting that most of the differences in participation among racial and ethnic groups remain unexplained and highlight the need for further investigation.