Publications by authors named "Reanna Dona-Termine"
Article Synopsis
- Vitamin D deficiency is widespread, particularly affecting women of childbearing age, and can increase the risk of immune problems in their children later in life.
- The study investigates how prenatal vitamin D deficiency impacts the immune cell makeup in offspring through experiments with vitamin D-deficient mice and analysis of data from 75 healthy pregnant women.
- Results show that low maternal vitamin D levels lead to changes in immune cell proportions in offspring, suggesting that the body retains a "memory" of prenatal vitamin D deficiency that affects immune development throughout life.
Vitamin D deficiency is a common deficiency worldwide, particularly among women of reproductive age. During pregnancy, it increases the risk of immune-related diseases in offspring later in life. However, exactly how the body remembers exposure to an adverse environment during development is poorly understood.
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- The study explores how Toxoplasma gondii, an intracellular parasite, influences the gene expression and chromatin state of human fibroblasts.
- It highlights a significant activation of host genes that can either protect the host or benefit the parasite, revealing a complex interaction between the two.
- The research combines genomic data from both host and parasite, leading to new insights into T. gondii’s genome, including a novel TATA box motif and the identification of transcription factors that impact both host and parasite physiology.
Vitamin D, a fat-soluble vitamin, plays a critical role in calcium homeostasis, the immune system, and normal development. Many epidemiological cohort studies globally have found high prevalence rates of vitamin D deficiency and insufficiency, recognized as an important health issue that needs to be solved. In particular, reproductive age and pregnant women low in vitamin D status may confer risks of diseases like obesity on their offspring.
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