Impact of the Current Versus the Previous Diagnostic Threshold on the Outcome of Patients With Borderline Changes Suspicious for T Cell-mediated Rejection Diagnosed on Indication Biopsies.

Background: Since the borderline changes suspicious for acute T cell-mediated rejection (BL) category was broadened, there has been a debate regarding the right threshold for tubulitis and interstitial inflammation scores.

Methods: We studied a first cohort of 111 patients with BL found on an indication biopsy between 2006 and 2016 and compared those with scores of t1i0 (BLt1i0) to those with higher scores (BL≥t1i1). A second cohort of 56 patients with BL was used for external validation.

Donor-specific antibodies, C4d and their relationship with the prognosis of transplant glomerulopathy.

Background: Transplant glomerulopathy (TG) is a diagnostic criterion for chronic active antibody-mediated rejection (CAABMR), with C4d, donor-specific antibodies (DSA) and other lesions of chronic tissue injury. However, TG often presents without C4d or DSA. Until recently, such cases were termed suspicious for CAABMR, and their prognosis remains unclear.

Impact of donor age on long-term outcomes after delayed graft function: 10-year follow-up.

Delayed graft function (DGF) has a negative impact on graft survival in donation after brain death (DBD) but not for donation after cardiac death (DCD) kidneys. However, older donor age is associated with graft loss in DCD transplants. We sought to examine the interaction between donor age and DGF in DBD kidneys.

Intralesional cidofovir in the treatment of cutaneous warts in a renal transplant patient.

Background: Cutaneous warts are often recalcitrant to conventional therapy in immunocompromised patients. Cidofovir is a potent antiviral agent shown to have a broad spectrum of action against DNA virus, including human papillomavirus.

Objective: To determine the efficacy of intralesional cidofovir in the treatment of florid warts in an immunocompromised renal transplant patient.

Dual-kidney transplants as an alternative for very marginal donors: long-term follow-up in 63 patients.

Background: Organ shortage has led to the use of dual-kidney transplant (DKT) of very marginal donors into a single recipient to increase the use of marginal organs. To date, few data are available about the long-term outcome of DKT and its usefulness to increase the pool of available organ.

Methods: We conducted a single-center cohort study of DKTs with longitudinal follow-up over an 8-year period.

Endothelin-1 levels and cardiovascular risk factors in renal transplant patients.

Objective: Circulating endothelin-1 (ET-1) levels have been reported to be associated with vascular complications and endothelial dysfunction in nontransplanted patients. The aim of this study was to investigate the relationship between ET-1 levels and major cardiovascular (CV) risk factors in renal transplant (RTX) patients with stable graft function.

Methods: ET-1 levels were determined in 156 RTX patients and the relationship between circulating ET-1 levels and CV risk factors including age, gender, kidney function, blood lipids, diabetes, and hypertension was studied.

Effects of prednisone withdrawal on the new metabolic triad in cyclosporine-treated kidney transplant patients.

Background: Cardiovascular disease is a major cause of morbidity and mortality after renal transplantation. Prednisone (Pred) maintenance therapy is associated with risk factors for atherosclerosis. Therefore, we were interested in quantifying the effects of Pred withdrawal on body weight and waist circumference as well as on metabolic markers of coronary heart disease risk.