Publications by authors named "Reaila Jianati"
[Research advances in the etiology and pathogenesis of immunoglobulin A vasculitis].
Zhongguo Dang Dai Er Ke Za Zhi
December 2023
Immunoglobulin A vasculitis (IgAV), also known as Henoch-Schönlein purpura, has complex etiology and pathogenesis which have not been fully clarified. The latest research shows that SARS-CoV-2 and related vaccines, human papilloma vaccine, and certain biological agents can also induce IgAV. Most studies believe that the formation of galactose-deficient IgA1 (Gd-IgA1) and Gd-IgA1-containing immune complex plays a crucial role in the pathogenesis of IgAV.
View Article and Find Full Text PDF[Inhibitory Effect of Cinobufotalin on Macrophage Inflammatory Factor Storm and Its Mechanism].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
June 2023
Article Synopsis
- The study aimed to explore how Cinobufotalin affects inflammation in monocytes and activated macrophages, investigating its molecular mechanisms.* -
- THP-1 cells were used to create macrophage activation models, and Cinobufotalin treatment showed a significant reduction in cell proliferation and increased apoptosis, especially in activated macrophages.* -
- Cinobufotalin's anti-inflammatory effects were linked to the inhibition of the TLR4/MYD88/P-IκBa signaling pathway, suggesting its potential for treating diseases related to excessive inflammation.*