Publications by authors named "Reagan Dominy"
J Neuroinflammation
June 2024
Article Synopsis
- - The study investigates the impact of a CLIP antagonist peptide (CAP) on B cell expansion and neuroprotective effects in 5xFAD mice, which are a model for Alzheimer's disease and have a history of traumatic brain injury (TBI).
- - Results showed that treatment with CAP significantly reduced CLIP-positive B cells and improved various impairments related to the immune system and neurobehavioral functions in the 5xFAD mice over a period of six months.
- - However, TBI seemed to negate the effectiveness of CAP in reducing B cell populations and also exacerbated several pathological features of Alzheimer's disease, indicating a complex interaction between TBI and AD.
