[Analysis of the mutation of BRCA1 gene in 70 Uigur women breast cancer patients in Xinjiang].

Objective: To analyze the mutations of BRCA1 in breast cancer patients of Uigur women in Xinjiang.

Methods: By using single strand conformation polymorphism (SSCP) and DNA sequencing, BRCA1 mutations were detected in 70 Uigur women breast cancer cases and 32 cases of benign breast diseases and non-tumor tissue next to carcinoma.

Results: (1) 12 new loci of BRCA1 gene mutation were detected firstly in 70 Uigur women breast cancer patients.