Unilateral Madarosis Revealing Blepharitis Caused by Microsporum audouinii: A Case Report.

Madarosis, defined as partial or total loss of eyelashes, is an unusual symptom that can reveal a variety of underlying conditions. We report a rare case of unilateral madarosis associated with blepharitis caused by Microsporum audouinii, a dermatophyte responsible for ringworms. An eight-year-old boy presented with ocular pruritus with erythematous squamous lesions of the right eyelid evolving for four days.

New nanomanufacturing strategy through bioinspired design, for promising treatment of Parkinson's disease.

This study attempts to develop a new nanomanufacturing strategy for Parkinson's disease using natural biodegradable components (chitosan, albumin, and dopamine) that can penetrate the blood-brain barrier (BBB) due to biocompatibility, biodegradability, targeted delivery, and controlled drug release. It was prepared, thoroughly optimized and characterized using various biophysical and chemical techniques. Results showed that the nanomanufactured system (molar ratio of 1:0.

The Unique Capability of Endolysin to Tackle Antibiotic Resistance: Cracking the Barrier.

The lack of new antibacterial medicines and the rapid rise in bacterial resistance to antibiotics pose a major threat to individuals and healthcare systems. Despite the availability of various antibiotics, bacterial resistance has emerged for almost every antibiotic discovered to date. The increasing prevalence of multidrug-resistant bacterial strains has rendered some infections nearly untreatable, posing severe challenges to health care.

Accidental Discovery of Ocular Cicatricial Pemphigoid.

Ocular cicatricial pemphigoid (OCP) is a chronic systemic autoimmune dermatosis characterized by progressive and fibrosing inflammation of the conjunctiva. We report the case of a 54-year-old female patient who presented with bilateral and progressive visual acuity loss. Clinical examination revealed trichiasis, bilateral symblepharon, bilateral superficial punctate keratitis, corneal opacity, and bilateral cataracts.

A Comparative Review of the Terms Epipharyngitis and Nasopharyngitis in Medical Literature.

This review explores the usage of the term "epipharyngitis" in medical literature, particularly in non-English-speaking contexts. The term, although rarely used in contemporary English-language medical literature, may lead to confusion due to its overlap with more commonly used terms like "nasopharyngitis." This review aims to trace the origins of the term, analyze its usage across different languages, and discuss the implications of term differences in clinical practice and medical education.

Ocular Involvement in Infantile Cystinosis: A Case Report.

Infantile cystinosis is a rare systemic hereditary disorder characterized by abnormal cystine accumulation in cells, leading to various complications. Ophthalmological involvement is one of the major complications of this condition and significantly impacts visual prognosis. We report the case of a five-year-old male patient who was followed up for growth retardation, rickets, and refractory metabolic acidosis and was referred to ophthalmology for severe photophobia.

Mass Screening for Primary Open-Angle Glaucoma: Is It Really Relevant?

Glaucoma, one of the leading causes of blindness worldwide, poses a significant public health challenge. Despite advancements in diagnostic technologies, early detection remains a challenge. This study assesses the relevance of glaucoma screening in a population-based context.

Thermoresponsive lipids engineered magnetic nanoparticles for spatiotemporal delivery of hesperidin to inflammatory sites in animal model.

Thermoresponsive nanoparticles are exploited as drug-delivery vehicles that release their payload upon increment in temperature. We prepared and characterized thermoresponsive lipid-anchored folic acid engineered magnetic nanoparticles (LP-HP-FANPs) that combine receptor-based targeting and thermoresponsive sustained release of hesperidin (HP) in response to endogenous inflammation site temperature. The progressive surface engineering of NPs was validated by FTIR analysis.

Ca binding shifts dimeric dual oxidase's truncated EF-hand domain to monomer.

Hydrogen peroxide, produced by Dual Oxidase (Duox), is essential for thyroid hormone synthesis. Duox activation involves Ca binding to its EF-hand Domain (EFD), which contains two EF-hands (EFs). In this study, we characterized a truncated EFD using spectrometry, calorimetry, electrophoretic mobility, and gel filtration to obtain its Ca binding thermodynamic and kinetics, as well as to assess the associated conformational changes.

Interaction of Semaglutide and Ziprasidone in a Patient With Schizophrenia: A Case Report.

Semaglutide (Ozempic), a GLP-1 receptor agonist effective in weight management, and ziprasidone (Geodon), an antipsychotic with a lower risk of metabolic side effects, are well-established in treating type 2 diabetes and schizophrenia, respectively. However, their interactions and effects on psychiatric symptoms are less understood. In this study, we report a case of a 43-year-old male with schizophrenia and diabetes with exacerbated paranoid delusions upon semaglutide administration for weight loss; symptoms peaked at higher doses and subsided after dose reduction.

Comparison of clinical characteristics, hospital treatment and outcomes in all four waves of Covid-19 patients at RTEH Muzaffargarh, Pakistan.

Background And Objective: The coronavirus pandemic followed a succession of COVID-19 waves globally, and had a varying pattern of frequency of cases and disease spectrum as each wave came with its distinct viral characteristics. The objective of this study was to compare clinical characteristics, treatments and outcomes of patients admitted with severe COVID -19 pneumonia in all four waves at Recep Tayyip Erdogan Hospital (RTEH).

Methods: A cross sectional retrospective study was conducted at the COVID unit of Recep Tayyip Erdogan Hospital (RTEH), Muzaffargarh, from April 2020 to December 2021.

Increased healthcare utilization in the year before multiple sclerosis diagnosis.

Background: Studies have suggested possible multiple sclerosis (MS) prodrome with non-routine healthcare utilization as an indicator. The objective of this project was to compare utilization in the four years (years -1, -2, -3, -4) before clinically definite diagnosis and examine demographic associations.

Methods: i2B2 database search at the Medical College of Wisconsin Comprehensive MS center yielded 613 patients between 07/01/2018 and 07/01/2022.

Hepatitis-C during Pregnancy: Antenatal period challenges, management and the way forward.

Pregnant women and the general public are both directly impacted by cirrhosis which is a chronic liver disease. It is also widely known that women who have a history of injectable drug use and cirrhosis are more prone to experience unfavorable consequences that have a negative impact on the health of both the mother and the unborn child. Higher maternal Hepatitis-C Virus (HCV) in pregnancy viral load, length of labor, use of amniocentesis or fetal scalp monitoring and protracted membrane rupture are all the risk of perinatal transmission of HCV in newborns.

A Case of COVID Cholangiopathy and Literature Review.

Introduction: With cholangiopathy, the bile ducts become inflamed and have a "beads on string appearance" with elevated bilirubin. It is typically associated with primary sclerosing cholangitis but is now being reported as a post-COVID complication.

Case Presentation: A 65-year-old White male presented with resolved respiratory failure from COVID-19 pneumonia, jaundice, and likely subacute kidney injury.

Effect of cooking methods on the nutritional quality of selected vegetables at Sylhet City.

The study was carried out to analyze the impacts of boiling, steaming, and microwave cooking on the physicochemical properties, the content of bioactive compounds, and boiling effect on mineral and heavy metal content of six widely consumed vegetables in Bangladesh's north-eastern region. In comparison to raw, boiled, and microwave-cooked vegetables, those that are steam-cooked retain a higher percentage of β-carotene with the exception of carrots. Boiling vegetables led to the most substantial reduction in ascorbic acid content (from 9.

Clinical and radiologic differences between early onset, late onset, and very late onset adult multiple sclerosis.

Background: Previous studies suggested possible differences in clinical and radiologic characteristics between early-onset multiple sclerosis (EOMS) and late-onset MS (LOMS). However, differences between LOMS and very late onset MS (VLOMS) are largely unknown.

Methods: We performed a retrospective review of medical records of patients diagnosed with MS between 8/1/2017 and 3/1/2022 at the comprehensive MS center of the Froedtert and Medical College of Wisconsin.

An extensive real-world in field tomato image dataset involving maturity classification and recognition of fresh and defect tomatoes.

Tomato, a fruiting plant species within the Solanaceae family, is a widely used ingredient in culinary dishes due to its sweet and acidic flavor profile, as well as its rich nutritional content. Recognized for its potential health benefits, including reducing the risk of coronary artery disease and specific types of cancer, tomatoes have become a staple in global cuisine. Traditional methods for tomato maturity assessment, harvesting, quality grading, and packaging are often labor-intensive and economically inefficient.

Mortal Dangers of Adult-Onset IgA Vasculitis.

IgA vasculitis (IgAV), previously known as Henoch Schoenlein purpura (HSP), is a leukocytoclastic vasculitis subtype predominantly amongst the pediatric patient population involving IgA dominant immune complex deposits attacking small vessel walls. While it oftentimes follows upper respiratory infections and presents with palpable purpuras, IgAV can also present in the adult patient population and lead to systemic inflammation. In this case report, we present the case of an adult-onset IgAV complicated via gastrointestinal perforation, acute kidney injury secondary to IgA nephritis, and circulatory shock.

Empyema Presentation Secondary to Streptococcus constellatus.

A 60-year-old male presented to our institution for abdominal pain and was later admitted to the intensive care unit for shock, acute hypoxemic respiratory failure, and acute kidney injury. He was subsequently found to have a large left-sided pleural effusion with empyema secondary to . With the emerging threat and growing prevalence of group pathogens, there is now greater clinical importance in identifying viridans streptococci at the species level.

Stigmatization as a Barrier to Urologic Care: A Review.

Heavy societal stigma of certain conditions has created an environment where individuals may be hesitant to seek professional care. Urology is a specialized field that focuses on many of these conditions that society has deemed taboo to discuss. In this review, we address barriers that have prevented patients from seeking urologic care in order to better understand and elucidate important concerns within development of the physician-patient relationship.

[Medico-surgical management of intravitreal hemorrhage in diabetic patients].

Vitreous hemorrhage (VH) is the main complication of proliferative diabetic retinopathy and remains the primary indication for vitrectomy in diabetic patients. The objective of our study is to compare our medical and surgical management of VH with data from the literature and to report the functional results of our series. We studied a series of 284 cases collected over 2 years in two tertiary care centers.