Skin signs of systemic infections and neoplastic diseases.

In recent years, emphasis on the physical examination has made way for a plethora of laboratory tests and sophisticated imaging diagnostic techniques. In addition, we are witnessing an underestimation of dermatology as a specialty around the world, which is accepted as an ambulatory specialty on the border of cosmetology and beautification. However, recognizing specific cutaneous clinical signs can facilitate timely diagnosis of various systemic infections and neoplastic diseases.

Evidence-based medicine: facts and controversies.

Evidence-based medicine is a paradigm shift in the biomedical field toward scientific-based clinical practice. It is recognized as the process of acquiring and applying into practice the best available research findings in a defined filed. Although the roots of evidenced-based medicine date back more than 150 years, the modern evidenced-based medicine concept has been rapidly and constantly developing in the past two decades.