Publications by authors named "Razvan-Nicolae Teodoreanu"
: Pressure injuries are localized areas of tissue damage or necrosis that occur when pressure is applied to the skin for prolonged periods, often over bony prominences, often the sacrum, heels, ischial tuberosities, and greater trochanters. The pathophysiology is complex, involving a combination of mechanical forces, ischemia, and tissue hypoxia. : We conducted a 2-year retrospective study aiming to assess the clinical characteristics, risk factors, and management of pressure injuries in patients admitted to an emergency hospital who underwent a plastic surgery examination.
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- The Buschke-Löwenstein tumor (BLT) is a rare, exophytic tumor linked to low-risk HPV strains, primarily appearing as a large, cauliflower-like growth in genital areas, which can be locally aggressive and has a notable recurrence rate.
- A 68-year-old patient with multiple health issues presented with a sizable tumor causing erectile dysfunction and urinary problems, which was successfully surgically excised with reconstruction.
- Histopathological analysis confirmed the diagnosis, and the patient's recovery underscores the importance of early diagnosis and surgical intervention to manage BLT and prevent complications like malignancy and recurrence.
: Hand septic arthritis is a potentially debilitating condition that can significantly affect patient functionality and quality of life. Understanding the demographic, clinical, and microbiological characteristics of this condition is crucial for its effective treatment and management. This study aimed to analyze the demographic and clinical profiles of patients with hand septic arthritis, to identify common microbial pathogens, and to evaluate the impact of various factors on clinical course and treatment outcomes.
View Article and Find Full Text PDFExploring Costimulatory Blockade-Based Immunologic Strategies in Transplantation: Are They a Promising Immunomodulatory Approach for Organ and Vascularized Composite Allotransplantation?
J Pers Med
March 2024
Article Synopsis
- The field of transplantation has advanced significantly since the first hand transplant in 1998, particularly in vascularized composite allotransplantation (VCA), which faces challenges like the need for lifelong immunosuppressive therapy.
- Current research aims to improve immunosuppressive strategies to reduce toxicity and foster donor-specific tolerance, emphasizing the role of costimulatory signals in T cell activation.
- This review summarizes data on costimulatory blockade as a potential method to prevent organ rejection and enhance the success of VCA, exploring new techniques for safer transplantation procedures.
Article Synopsis
- - Abrikossoff tumors, or granular cell tumors, arise from Schwann cells and are most commonly found in the oral cavity, though they can also occur in other parts of the body like the skin, breast, and central nervous system.
- - These tumors usually affect individuals between 30 and 50 years old, are slightly more common in females, and are primarily benign, with malignant cases being rare (less than 2%).
- - Diagnosis is made through immunohistochemical tests, and treatment typically involves surgical removal; however, chemotherapy and radiotherapy may be needed for malignant tumors, although their effectiveness isn’t well established. The text includes a case study of a 12-year-old girl with a benign GCT
Benign and malignant cartilaginous bone tumors of the hand are rare findings, however representing a particular pathology due to the capacity to induce significant functional impairment. Even though a large proportion of tumors of the hand and wrist are benign, these may present destructive characteristics, deforming adjacent structures until compromising function. The most appropriate surgical approach for most benign tumors is intralesional lesion resection.
View Article and Find Full Text PDFDermatofibrosarcoma protuberans (DFSP) is a rare soft tissue tumor that is classified as a non-melanoma skin cancer. Surgical excision with wide safety margins is the cornerstone treatment and frequently requires advanced reconstruction methods for wound closure. This study aimed to report our experience with the management of seven consecutive patients with dermatofibrosarcoma protuberans.
View Article and Find Full Text PDFBenign peripheral nerve tumors and malignant peripheral nerve tumors are rarely found in patients with upper limb tumors. A four-year retrospective study was conducted on patients with tumors in the upper limb area admitted to the Emergency Clinical Hospital, Bucharest, Romania. Seventeen patients were admitted within this time range, 15 of which were benign and two malignant.
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- The study examined periorbital burn injuries in 126 severely burned patients, focusing on factors like demographics, burn severity, and ocular injuries.
- Major risk factors included advanced age, extensive and deep burns, and inhalation injuries, which were linked to high morbidity and mortality rates.
- Effective treatment for ocular injuries is crucial to prevent vision loss, highlighting the importance of preventive measures and timely ophthalmologic care in severely burned patients.
Injuries by high voltage electrocution represent rare and very complex accidents. In order to provide support to surgical therapy, to limit the extension of injuries or to support the natural process of tissue repair, we oriented towards the use of two growth factors, insulin and platelet-enriched plasma (PRP) administered locally, on the injury site. The therapeutic protocol was applied on three cases of electrocution with promising results in reducing the duration of surgical and pharmacological treatment and of time of hospitalization.
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