Expression of VEGF and CD-31 in traumatic ulcer of diabetic Wistar rats after application of peel essential oil.

Objective: Diabetes mellitus (DM) is a metabolic disease that delays the healing process, including the interruption of the processes of angiogenesis and vasculogenesis. The etiology of most angiogenic-related diseases, such as diabetes complications, includes the presence of hypoxia caused by declined vascular endothelium growth factor (VEGF) and CD-31. d-limonene, one of the main constituents of , is considered to have angiogenic, antioxidant, hypoglycemic, and anti-inflammatory activities.