Meldonium long-term excretion period and pharmacokinetics in blood and urine of healthy athlete volunteers.

Meldonium is a metabolic drug whose inclusion in the 2016 List of Prohibited Substances and Methods followed the analysis of data collected under the 2015 World Anti-Doping Agency Monitoring Program. In the early months of 2016, anti-doping laboratories reported an unusually high number of cases in which urine samples contained high concentrations of meldonium. Consequently, the meldonium excretion period in healthy athletes and the substance's long-term urine and blood (plasma) pharmacokinetics became central questions for the anti-doping community to address, to ensure appropriate assessment of the scientific and medical situation, and also fair treatment of athletes from a result management and legal standpoint.

[Method of individual evaluation of athletes' tolerance of maximal physical exertion under exposure to changed hypoxic and hypothermal environment].

The article covers a program determining order and method of gradual examination of highly qualified athletes engaged into winter sports in Sports Medicine and Rehabilitation Center in Bournazian FMBC of the FMBA of Russia, to assess physical performance and individual tolerance in changed climate (hypoxic and hypothermal) conditions.

[Self-evaluation of health state in athletes].

The article covers scientific basis and elaboration of system concerning self-evaluation of athletes' health state. The study comprised 2 steps. During the first step, a group of 62 athletes (45 males and 17 females) performed methods of self-evaluation of health state through a list of changes, tests and stress testing.

[The estimation of correlation dependences between the results of clinical examination and screening diagnostics of the risk factors of the development of cardiovascular diseases in the women of late reproductive age].

The results of clinical trials give evidence of the close correlation between the data obtained by clinical, biochemical, and instrumental methods and the data of screening studies designed to estimate the risk factors responsible for the development of cardiovascular diseases in the women of late reproductive age.

[Electric impulse therapy of hypertensive patients].

Patients with mild arterial hypertension and hypersympathicotonia treated with electroimpulse therapy improved their clinicofunctional state, blood pressure (especially systolic pressure), its variability, sympathic activity, central regulation of cardiac rhythm, capillary reserves.

[Criterion significance of erythrocyte membranes adrenoreceptors functional index for evaluating the functional state of human operator].

In 30 human volunteers who performed operator activity for 25 min on the stand trainer there have been determined the pre- and post-operation magnitude of beta-adrenoception of the cellular membranes (beta-APM) by applying the author's method (Russian Federation Patent), hemodynamic indices, osmoresistance of erythrocytes and the content of total bilirubin in the blood. The quality of operator activity was determined from the amount of erroneous actions and from time (T) spent for their clearing. There exists the direct correlation between the magnitudes of beta-APM and T within the mean ranges of their magnitudes (on evidence derived from histograms).

[Individual characteristics of changes in the functional state of a human operator in a simulated long-term flight aboard a single-seat airplane].

In the 12-hour experiment with simulation of habituation factors in the cabin of one-seat aeroplane the individual dynamics of indices in 29 men (volunteers) has been studied. The reactive-situational anxiety, self-rating, heart rate, arterial pressure, blood glucose level, operator working capacity have been recorded. There have been revealed the twelve types of individual dynamics of the indices: linear increase or decrease, elevation or decline with stabilization of an indicator level, stable with a consequent elevation (decline), step-wise increase (decrease), P- and U-shaped wave-shaped dynamics and practically constant level have been recorded.

[Features of changes in psychophysiological state of operators exposed to high temperatures].

Having analyzed the scientific materials, the author stresses the absence of unified theory on psychophysiologic changes caused in operators by high ambient temperatures. The personal research proved that high ambient temperatures (45-60 C with humidity at 10-15%) cause worse psychophysiologic state of operators since beginning of the exposure. The author considers that it could result from excess of the skin weighted average temperature over the rectal one.

[The characteristics of the action of ethanol in operators with different states of the skin tissue basophils].

The changes in some parameters of an operator activity after ethanol administration at a dose of 1.9 g/kg body weight in 10 men doing the job of two-dimensional compensatory tracking in simulator, have been studied. In this case, the population state of tissue basophils (mast cells) of the body by studying the amounts of various structural and metabolic forms of these cells, contained in the skin biopsies, was studied.

[Various indicators of brain metabolism during hypoxia and hyperthermia].

Hypoxic, thermal and radiation tolerance of rats exposed to hypoxia and overheating for 4 to 22 days was measured. Activities of succinic dehydrogenase, lactate dehydrogenase and alkaline phosphomonoesterase as well as water content in the brain were examined biochemically and histochemically. Brain tolerance and metabolism varied in a phasic manner.

[Short-term action of high carbon monoxide concentrations on the psychophysiological functions of a human operator].

Experiments on volunteers, aged 26-40, demonstrated that a 10-minute exposure to carbon monoxide at a concentration of 900 +/- 20 mg/m3 caused a significant decline of the quality of their operator's function. The task they performed was a two-dimensional compensatory tracking task combined with mental arithmetic. Some of the test subjects showed symptoms of mild CO intoxication which preceded disorders in their work and were accompanied by an increase of HbCO to 10 +/- 0.

[Evaluation of adaptation of animals to hypoxic hypoxia by the multiple regression method].

White mice were exposed to hypoxic hypoxia during 30 days. In the study a correlation between the altitude ceiling and various physiological parameters (body weight, body temperature variations in response to a cold stress (5 degrees C), hemoglobin content, coefficients of adaptive oxygen consumption determined as the ratio of oxygen consumption at 6000 m to that at sea level (K1) and the ratio of oxygen consumption in hypoxic environment to that in a normoxic atmosphere (K2) was established. The data obtained allow the conclusion that the multiple regression method can be used for measuring objectively the tension of regulatory systems and for discriminating stages of animal adaptation to hypoxic hypoxia.