Harnessing ctDNA in Advanced Melanoma: A Promising Tool for Informed Clinical Decisions.

Cutaneous melanoma, an aggressive malignancy, has undergone significant transformation in clinical management with the introduction of immune checkpoint inhibitors (ICIs) and targeted therapies. Current monitoring methods, such as imaging scans, present limitations, prompting exploration of alternative biomarkers. This review comprehensively explores the role of circulating tumor DNA (ctDNA) in advanced melanoma, covering technical aspects, detection methods, and its prognostic and predictive value.

Stress Management in Healthcare Organizations: The Nigerian Context.

Occupational psychosocial stress can increase the risk of several cardiometabolic diseases. Healthcare workers worldwide experience exceptionally high levels of occupational stress, leading to serious individual, organizational, and societal problems. This narrative review seeks to provide information about the overall consequences of having over-stressed healthcare workers and ascertain how it eventually holds back the advancement of healthcare.

Changing Epidemiological Patterns of Infection and Mortality Due to Hepatitis C Virus in Poland.

Introduction: Limited information is available on trends in hepatitis C virus (HCV) infection, particularly in Central Europe. To address this knowledge gap, we analyzed HCV epidemiology in Poland, considering socio-demographic characteristics, changing patterns over time, and the impact of the COVID-19 pandemic.

Material And Methods: We examined HCV cases (diagnosis and deaths) reported by national registries and used joinpoint analysis to estimate time trajectories.

Listeriosis During Pregnancy: Maternal and Neonatal Consequences-A Case Report.

Listeriosis is a rare but extremely dangerous infection for both mother and fetus. This pathogen can spread in humans' bodies by consumption of contaminated food. The main high-risk groups of people for being infected are immunosuppressed and especially pregnant women.

Is the Leptin/Adiponectin Ratio a Better Diagnostic Biomarker for Insulin Resistance than Leptin or Adiponectin Alone in Adolescents?

Background: Recently, the leptin/adiponectin (L/A) ratio has been suggested as a novel predictor of cardio-metabolic and other chronic diseases. Aim: To evaluate the ability of leptin (L), adiponectin (A), and the L/A ratio in identifying high risk of insulin resistance IR in adolescents, adjusted by cardiorespiratory fitness, adherence to the Mediterranean diet, and body fat percentage. Subjects and methods: This is a cross-sectional analysis with 529 adolescents aged 12−18 years-old.

Bullying and Health Related Quality of Life among Adolescents-A Systematic Review.

Health-related quality of life is among global health goals not only in adulthood but also in childhood and adolescence. Being a multi-component construct, health-related quality of life covers various domains, such as physical and psychological wellbeing and social and environmental areas. Bullying might significantly influence those domains especially in adolescence, a period of life when numerous personal and interpersonal transformations are experienced.

Identification of Good Practices in Long-Term Exercise-Based Rehabilitation Programs in Stroke Patients.

Physical activity is an important factor for primary and secondary stroke prevention. The process of stroke rehabilitation includes early and late physical activity and exercise, which prevents further stoke and improve patients' quality of life. MY WAY project, an ERASMUS+ SPORT program, is aimed at analyzing and developing or transferring best innovative practices related to physical activity and exercise enhancing health in poststroke patients.

Long-Term Effect of an Exercise Training Program on Physical Functioning and Quality of Life in Pulmonary Hypertension: A Randomized Controlled Trial.

The aim of this study was to evaluate the effects of a 6-month combined aerobic and strength exercise training program on functional and psychological aspects and health-related quality of life in patients with PH and to evaluate its longer-term impact. In total, 22 stable patients (mean age 53.9 ± 13.

Balneotherapy for musculoskeletal pain: does the mineral content matter?

Musculoskeletal pain is a health challenge with various treatment strategies. The study has been accomplished with the aim to reveal the effect of mineral water with different mineral content on musculoskeletal pain and related symptoms experienced. A randomized controlled single-blinded parallel-group study has been performed (145 participants with pain; 5 groups).

HIFU treatment for fibroadenoma - a clinical study at National Scientific Research Centre, Astana, Kazakhstan.

This randomized controlled study evaluated effect of low frequency high intensity focused ultrasound (HIFU) in 80 women with breast fibroadenomas randomly and evenly divided into main and control groups, treated with HIFU and sectoral resection accordingly. In- vitro trial of fibroadenoma samples exposed to different power levels:100 Watt (W), 200 W and 300 W, analysis of results shown that optimal ablation power 200W was enough for coagulation necrosis of tumour, while 300W ablation caused complete destruction of tissues. Results showed that 20% of control group (surgically treated) patients had post-operative complications and 12.

Short-Term and Long-Term Effects of Riding for Children with Cerebral Palsy Gross Motor Functions.

. To evaluate the effects of riding for beginners (short-term) and advanced (long-term) riders with cerebral palsy on their whole mobility. The study involved 15 subjects (two girls and eleven boys).

Stress and Fatigue Management Using Balneotherapy in a Short-Time Randomized Controlled Trial.

Objective. To investigate the influence of high-salinity geothermal mineral water on stress and fatigue. Method.

The reduction of distress using therapeutic geothermal water procedures in a randomized controlled clinical trial.

Stress is an element of each human's life and an indicator of its quality. Thermal mineral waters have been used empirically for the treatment of different diseases for centuries. Aim of the Study.

Work-related empowerment of nurse managers: a systematic review.

The present study discusses how nurse managers' work-related empowerment has been investigated, in order to determine the level and relationships of empowerment among them. A systematic review was carried out, and a literature search was conducted with certain electronic databases for the period 1990-2009, using the main key words in various combinations. Only nine empirical studies in English were selected for review, in accordance with the requirements for the methodological quality and inclusion criteria.

Research on the quality of abdominal surgical nursing care: a scoping review.

Various health care measures have been identified over the years as indicators of health care quality. However, studies evaluating the quality of nursing care among different patient groups are scarce. Patients undergoing abdominal surgery may be a group that has different views, needs, expectations, and evaluation of the quality of nursing care.

Competence of nurses and factors associated with it.

Objective: Nurse competence became a relevant topic for discussion among nurse practitioners and nurse researchers. However, the factors connected with nurse competence need deeper exploring. The aim of this study was to explore nurse competence and factors associated with it from the perspective of nurses for predicting the possible ways for upgrading the nursing practice.

Lithuanian nurses' assessments of their empowerment.

Aims And Objectives: The aim was to explore nurse empowerment and the factors associated with it from the viewpoint of surgical nurses.

Design: A multicentre cross-sectional, descriptive, correlational study design was used.

Setting And Participants:   The data were collected from 11 units of seven largest Lithuanian hospitals located in three major cities during the period of 11/2007 to 01/2008.

Psychological distress in patients with benign voice disorders.

Objective: The aims of this study were to investigate the frequency of anxiety and depression in patients with benign voice disorders with respect to gender and diagnosis and to determine correlations between psychological distress and some sociodemographic factors and the Voice Handicap Index (VHI).

Methods: Psychological distress was assessed for 437 consecutive adult patients with benign voice disorders and 88 healthy controls by a standardized Hospital Anxiety and Depression Scale (HADS). In addition, sociodemographic factors, unhealthy habits and VHI were investigated.

Nurses' perceived work-related empowerment in Lithuanian context.

Unlabelled: STUDY'S RATIONALE: Empowerment is widely used within the nursing literature in different countries, but perceived empowerment of Lithuanian nurses has not been studied before. There is a lack of research which has analysed nurses' views and feelings of empowerment.

Aims And Objectives: The aim of this study was to describe the perception of Lithuanian nurses' work-related empowerment.

The impact of an education intervention to change nurses' HIV-related knowledge and attitudes in Lithuania: a randomized controlled trial.

The purpose of this study was to describe the effect of an intervention program on nurses' HIV-related knowledge and attitudes in Lithuania. The program focused on HIV epidemiology, transmission, coinfections, treatment and care, risk contacts, and moral and ethical dilemmas. It was designed to increase nurses' knowledge and positive attitudes concerning HIV.

Nurses' willingness to take care of people living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)--does a teaching intervention make a difference?

Unlabelled: The aim of this study is to describe the impact of an education intervention programme on nurses' willingness to care for HIV-positive people in Lithuania.

Methods: The study utilizes a randomized controlled trial design (RCT). The total sample comprises 185 nurses working in medical, surgical and gynaecological units, and primary health care centres from the same hospital areas in three Lithuanian hospitals.

Impact of intervention programs on nurses' knowledge, attitudes, and willingness to take care of patients with human immunodeficiency virus/acquired immunodeficiency syndrome: a descriptive review.

Objective: This paper reviews the current literature on intervention programs designed to improve nurses' knowledge and attitudes to human immunodeficiency virus/acquired immunodeficiency syndrome and their willingness to take care of patients with human immunodeficiency virus/acquired immunodeficiency syndrome. It also explores the impact of these intervention programs.

Materials And Methods: The MEDLINE and Pubmed, Science Direct, Cochrane Library, EbscoHost, ERIC databases were searched for relevant English-language citations between 1997 and 2007 using the following search terms: human immunodeficiency virus/acquired immunodeficiency syndrome, nurse, intervention, teaching, education, knowledge, attitude, and willingness.

The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial.

Malignant ascites is a common manifestation of advanced cancers, and treatment options are limited. The trifunctional antibody catumaxomab (anti-epithelial cell-adhesion molecule x anti-CD3) represents a targeted immunotherapy for the intraperitoneal (i.p.

Competence of general practice nurses caring for patients with mental health problems in the somatic departments.

OBJECTIVE. To investigate competence of general practice nurses caring for patients with mental health problems in the somatic departments. MATERIAL AND METHODS.