Drug Repositioning for Scorpion Envenomation Treatment Through Dual Inhibition of Chlorotoxin and Leiurotoxin.

Scorpion envenomation, a grave public health concern, is primarily driven by the potent neurotoxins chlorotoxin and leiurotoxin present in Leiurus species venom. Developing effective treatments is crucial to mitigate its impact. Utilizing a drug-repositioning bioinformatics-based approach, potential inhibitors of these neurotoxins were identified from Food and Drug Administration (FDA)-approved drugs.

Environmental determinants of venom variability in captive scorpions: A comprehensive analysis of diet, temperature, and humidity effects.

This study examines the effects of environmental conditions on venom production in four prevalent scorpion species in Morocco: Androctonus amoreuxi, Androctonus mauretanicus, Buthus mardochei, and Scorpio maurus. The research focuses on how climatic factors such as temperature, humidity, and diet-specifically mealworm consumption-affect physical parameters including size and weight, and ultimately venom yield. We conducted a comprehensive investigation involving the capture, acclimatization, and systematic venom extraction from 480 scorpions.