Publications by authors named "Razan Alawaji"
To synthesize a silver-cored nanosuspension utilizing fresh-leaf extract and evaluate their antimicrobial activity against multidrug-resistant pathogenic microbes. The prepared nanosuspension was analyzed by spectro-analytical techniques and tested for antimicrobial activity and resistance to biofilm formation. The leaf extract and nanosuspension were tested separately and together as a mixture.
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- - The study focuses on the interaction between the tumor suppressor p53 and the MDM2 protein, which negatively regulates it, highlighting their importance in cancer drug discovery.
- - Researchers analyzed 120 lignans from the plant Ferula sinkiangensis, identifying nine compounds with stronger binding to MDM2 than the reference drug Nutlin-3a, with three compounds selected for further study due to their high binding affinities.
- - A 100 ns molecular dynamics simulation confirmed the stability of the selected candidates, suggesting they could be promising leads for anti-cancer therapies, although further synthesis and testing are required.