A water-responsive calix[4]resorcinarene system: self-assembly and fluorescence modulation.

This study explores how water content modulates the self-assembly and fluorescence behavior of two novel calix[4]resorcinarene macrocycles. These macrocycles transition from large, flattened structures in pure THF to large giant vesicles (500-5000 nm) coexisting with small micelles (3.4-3.

Thermoresponsive lipids engineered magnetic nanoparticles for spatiotemporal delivery of hesperidin to inflammatory sites in animal model.

Thermoresponsive nanoparticles are exploited as drug-delivery vehicles that release their payload upon increment in temperature. We prepared and characterized thermoresponsive lipid-anchored folic acid engineered magnetic nanoparticles (LP-HP-FANPs) that combine receptor-based targeting and thermoresponsive sustained release of hesperidin (HP) in response to endogenous inflammation site temperature. The progressive surface engineering of NPs was validated by FTIR analysis.

Synthesis and characterization of honey based hybrid dental implants with enhanced antibacterial activity.

Dental implants are commonly used for tooth replacement tools due to their good oral rehabilitation and reconstruction capacities. Dental implants treatment for natural teeth is desired to achieve successful implants treatment with improved osseointegration through promotion of mammalian cell activity and prevention of bacterial activity. Honey is potentially known for its antimicrobial and antibacterial potential, specifically for burns and wound healing.

The effect of water in THF/water mixtures on CMC, aggregation sizes, and fluorescence quenching of a new calix[4]resorcinarene macrocycle.

This study explores how water content modulates the self-assembly and fluorescence behavior of a novel calixarene, C1. C1 forms large, flattened structures in pure THF, but water addition triggers a transition to smaller, unimodal clusters. A critical micellar concentration (CMC) is identified, decreasing with increasing water content.

Enhancing System Performance through Objective Feature Scoring of Multiple Persons' Breathing Using Non-Contact RF Approach.

Breathing monitoring is an efficient way of human health sensing and predicting numerous diseases. Various contact and non-contact-based methods are discussed in the literature for breathing monitoring. Radio frequency (RF)-based breathing monitoring has recently gained enormous popularity among non-contact methods.

BER Reduction and Capacity Enhancement with Novel Guard Sequence Selection for Multi-Carrier Communication.

Orthogonal frequency division multiplexing (OFDM) is an efficient multicarrier scheme that uses different types of guard intervals such as cyclic prefix (CP) and known symbol padding (KSP) (zero padding (ZP), unique word (UW), etc.) in block formation. Among these guard intervals, CP varies for each block, while other guard intervals remain fixed from block to block.

Nanovesicles containing curcumin hold promise in the development of new formulations of anti-Acanthamoebic agents.

In this study, curcumin-nanoformulations were tested for anti-Acanthamoebic properties. Curcumin-loaded nanovesicles were synthesized, followed by characterization with Fourier transform infrared spectroscopy, ultraviolet-visible spectrophotometry, and atomic force microscopy. Using amoebicidal assay, the effects of curcumin-nanoformulations were investigated against A.

Improving Machine Learning Classification Accuracy for Breathing Abnormalities by Enhancing Dataset.

The recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease (COVID)-19, has appeared as a global pandemic with a high mortality rate. The main complication of COVID-19 is rapid respirational deterioration, which may cause life-threatening pneumonia conditions. Global healthcare systems are currently facing a scarcity of resources to assist critical patients simultaneously.

Synthesis and antimicrobial activity of 1-1,2,3-triazole and carboxylate analogues of metronidazole.

Herein, a series of novel 1-1,2,3-triazole and carboxylate derivatives of metronidazole ( and ) were synthesized and evaluated for their antimicrobial activity in vitro. All the newly synthesized compounds were characterized by H NMR, C NMR, HRMS, and F NMR (, and ) spectroscopy wherever applicable. The structures of compounds , and were unambiguously confirmed by single crystal X-ray analysis diffraction method.

Preexisting opioid use disorder is associated with poor outcomes in hospitalized acute pancreatitis patients.

Introduction: Although opioids are widely used for pain management in acute pancreatitis, the impact of opioid use disorder (OUD) on outcomes in patients with acute pancreatitis remains unknown. In the current study, we aimed to evaluate the impact of the OUD on outcomes in patients hospitalized with acute pancreatitis and delineate the trends associated with OUD and acute pancreatitis using a nationally representative sample.

Methods: This is a retrospective cohort study of patients with acute pancreatitis using the combined releases of the year 2005-2014 of the National (Nationwide) Inpatient Sample (NIS) database.

RF Sensing Based Breathing Patterns Detection Leveraging USRP Devices.

Non-contact detection of the breathing patterns in a remote and unobtrusive manner has significant value to healthcare applications and disease diagnosis, such as in COVID-19 infection prediction. During the epidemic prevention and control period of COVID-19, non-contact approaches have great significance because they minimize the physical burden on the patient and have the least requirement of active cooperation of the infected individual. During the pandemic, these non-contact approaches also reduce environmental constraints and remove the need for extra preparations.

Contactless Small-Scale Movement Monitoring System Using Software Defined Radio for Early Diagnosis of COVID-19.

The exponential growth of the novel coronavirus disease (N-COVID-19) has affected millions of people already and it is obvious that this crisis is global. This situation has enforced scientific researchers to gather their efforts to contain the virus. In this pandemic situation, health monitoring and human movements are getting significant consideration in the field of healthcare and as a result, it has emerged as a key area of interest in recent times.

Highly selective, sensitive and simpler colorimetric sensor for Fe detection based on biosynthesized gold nanoparticles.

Herein, we describe the fabrication of green bell pepper, Capsicum annuum L. extract capped gold nanoparticles (CA-AuNPs) in aqueous medium using tetrachloroaurate (HAuCl·3HO) as precursor salt and sodium hydroxide (NaOH) solution as accelerator as well as pH adjuster. Formation of CA-AuNPs was verified via colour change from yellowish to ruby red with further confirmation through surface plasmon resonance (SPR) band at 519 nm using ultraviolet violet-visible (UV-Vis) spectroscopy.

Selective Arylation of 2-Bromo-4-chlorophenyl-2-bromobutanoate via a Pd-Catalyzed Suzuki Cross-Coupling Reaction and Its Electronic and Non-Linear Optical (NLO) Properties via DFT Studies.

In the present study, 2-bromo-4-chlorophenyl-2-bromobutanoate () was synthesized via the reaction of 2-bromo-4-chlorophenol with 2-bromobutanoyl bromide in the presence of pyridine. A variety of 2-bromo-4-chlorophenyl-2-bromobutanoate derivatives (-) were synthesized with moderate to good yields via a Pd-catalyzed Suzuki cross-coupling reaction. To find out the reactivity and electronic properties of the compounds, Frontier molecular orbital analysis, non-linear optical properties, and molecular electrostatic potential studies were performed.

Synthesis of biocompatible triazole based non-ionic surfactant and its vesicular drug delivery investigation.

Numerous nanotechnological approaches have been widely practiced to improve the bioavailability of less aqueous soluble drugs; phospholipid based vesicles (liposomes) being the most widely applied drug delivery system. However; due to stability issues, large scale production limitations, sterilization and long term storage problems; non-ionic surfactant based vesicles (niosomes) are considered their excellent counterparts. Niosomes are vesicles of non-ionic surfactants having the ability to carrying both hydrophilic and hydrophobic drugs in their inner aqueous or lipid bilayer compartments.

Metal nanoparticles fabricated by green chemistry using natural extracts: biosynthesis, mechanisms, and applications.

Nanoparticles (NPs) are new inspiring clinical targets that have emerged from persistent efforts with unique properties and diverse applications. However, the main methods currently utilized in their production are not environmentally friendly. With the aim of promoting a green approach for the synthesis of NPs, this review describes eco-friendly methods for the preparation of biogenic NPs and the known mechanisms for their biosynthesis.

Oleic Acid Coated Silver Nanoparticles Showed Better Amoebicidal Effects against than Amphotericin B.

() causes primary amoebic meningoencephalitis (PAM) which almost always results in death. also known as "brain-eating amoeba" due to its literal infestation of the brain leading to an inflammatory response in the brain tissues. Currently, there is no single drug that is available to treat PAM, and most treatments are combinations of antifungal, anticancer, and anti-inflammatory drugs.

Antidiabetic Drugs and Their Nanoconjugates Repurposed as Novel Antimicrobial Agents against Acanthamoeba .

belonging to the T4 genotype may cause a fatal brain infection known as granulomatous amoebic encephalitis, and the vision-threatening eye infection keratitis. The aim of this study was to evaluate the antiamoebic effects of three clinically available antidiabetic drugs, Glimepiride, Vildagliptin and Repaglinide, against belonging to the T4 genotype. Furthermore, we attempted to conjugate these drugs with silver nanoparticles (AgNPs) to enhance their antiamoebic effects.

Silver Nanoparticle Conjugation-Enhanced Antibacterial Efficacy of Clinically Approved Drugs Cephradine and Vildagliptin.

This paper sets out to determine whether silver nanoparticles conjugation enhance the antibacterial efficacy of clinically approved drugs. Silver conjugated Cephradine and Vildagliptin were synthesized and thoroughly characterized by ultraviolet visible spectrophotometry (UV-vis), Fourier transform infrared (FT-IR) spectroscopic methods, atomic force microscopy (AFM), and dynamic light scattering (DLS) analysis. Using antibacterial assays, the effects of drugs alone and drugs-conjugated with silver nanoparticles were tested against a variety of Gram-negative and Gram-positive bacteria including neuropathogenic K1, , , methicillin-resistant (MRSA), and .

Gold Nanoparticles Conjugation Enhances Antiacanthamoebic Properties of Nystatin, Fluconazole and Amphotericin B.

Parasitic infections have remained a significant burden on human and animal health. In part, this is due to lack of clinically-approved, novel antimicrobials and a lack of interest by the pharmaceutical industry. An alternative approach is to modify existing clinically-approved drugs for efficient delivery formulations to ensure minimum inhibitory concentration is achieved at the target site.

Clinically Approved Drugs against CNS Diseases as Potential Therapeutic Agents To Target Brain-Eating Amoebae.

Central nervous system (CNS) infections caused by free-living amoebae such as Acanthamoeba species and Naegleria fowleri are rare but fatal. A major challenge in the treatment against the infections caused by these amoebae is the discovery of novel compounds that can effectively cross the blood-brain barrier to penetrate the CNS. It is logical to test clinically approved drugs against CNS diseases for their potential antiamoebic effects since they are known for effective blood-brain barrier penetration and affect eukaryotic cell targets.

N-(2-hydroxyphenyl)acetamide and its gold nanoparticle conjugation prevent glycerol-induced acute kidney injury by attenuating inflammation and oxidative injury in mice.

The protective activity of N-(2-hydroxyphenyl)acetamide (NA-2) and NA-2-coated gold nanoparticles (NA-2-AuNPs) in glycerol-treated model of acute kidney injury (AKI) in mice was investigated. NA-2 (50 mg/kg) and NA-2-AuNPs (30 mg/kg) were given to the animals for four days followed by 24-h water deprivation and injection of 50% glycerol (10 ml/kg im). The animals were sacrificed on the next day.