Free radical synthesis of succinic anhydride grafted poly(lactic acid) porous templates for sustained drug delivery in the buffer media.

Poly(lactic) (PLA) is a biodegradable material obtained from renewable resources and is recognized as a safe biopolymer by the Food and Drug Administration. PLA expresses excellent mechanical and moldability attributes nonetheless poor elasticity/functionality limits its widespread utilization. One approach to compensate for this is chemical surface modification through free radical grafting with small organic molecules like maleic anhydride (MA).

Catheter-Related Bloodstream Infections Among Hemodialysis Patients in Northern Tanzania: Insights From a Single-Centre Retrospective Study.

Background And Aims: A catheter-related bloodstream infection (CRBSI) is a life-threatening complication of hemodialysis. It is responsible for significant morbidity and mortality and a costly long hospital stay. Despite its burden, little is known about the factors associated with it and the antibiogram of its responsible causative bacteria.

Citronellol Induces Apoptosis via Differential Regulation of Caspase-3, NF-κB, and JAK2 Signaling Pathways in Glioblastoma Cell Line.

Citronellol (CT) is a naturally occurring lipophilic monoterpenoid which has shown anticancer effects in numerous cancerous cell lines. This study was, therefore, designed to examine CT's potential as an anticancer agent against glioblastoma (GBM). Network pharmacology analysis was employed to identify potential anticancer targets of CT.

Novel Transfer Learning Approach for Detecting Infected and Healthy Maize Crop Using Leaf Images.

Maize is a staple crop worldwide, essential for food security, livestock feed, and industrial uses. Its health directly impacts agricultural productivity and economic stability. Effective detection of maize crop health is crucial for preventing disease spread and ensuring high yields.

Effects of stocking density on growth performance, digestive enzyme activity, biochemical composition, and economic efficiency of a new strain of reared in cage culture system at Sindh Pakistan.

The latest strain of is an altered ecological adaptation for sustainable aquaculture and is necessary to sustain stocking density and reduce physiological stress of the new strain. The present study aimed to determine the optimum stocking density, biological performance, and economic efficiency of the Nile tilapia. The 14,000 healthy seeds and uniform weight (40 ± 2.

A Rare Case of Dysphagia: A Case Report.

Unlabelled: Esophageal leiomyomas (EL) are the most common benign tumors of the esophagus, being pedunculated polyp presentation is very rare. A 65-year-old female presented with symptoms of troublesome dysphagia. Esophagogastroduodenoscopy (EGD) performed revealed a pedunculated polyp of ~ 3 × 1.

Quantifying sustainable urbanization by predictive modeling for better agricultural management: A case study in the South Asiatic Region.

Global population growth and uncontrolled are creating threats to agricultural land. To address urbanization, proactive planning is required. Land use and land cover (LULC) classification maps for 2002-2022 were analyzed using remote sensing (RS) and geographic information systems (GIS) in Sahiwal, Punjab, Pakistan.

Evaluating Outcomes of Step-Cut Osteotomy for Pediatric Cubitus Deformities.

Introduction: Supracondylar fractures in children often result in malunion and subsequent cubitus varus or valgus deformity. While often considered cosmetic, these deformities can lead to pain, functional impairment, and other complications. Corrective osteotomy is a common treatment option, with step-cut osteotomy being a preferred method due to its effectiveness and relative simplicity.

Unveiling Pediatric Neurosarcoidosis Mimicking Central Nervous System Tuberculosis: Diagnostic Challenges.

Neurosarcoidosis is a rare chronic inflammatory disease affecting the nervous system. Owing to its varying manifestations that can mimic other central nervous system infectious or autoimmune diseases, and scarcity of literature, it proves to be a challenging diagnosis. We report two cases of possible neurosarcoidosis in the pediatric age group.

Interhospital Variability in 180-day Infections Following Cardiac Surgery.

Objective: This study sought to: (1) evaluate hospital-level variation in infections following cardiac surgery and (2) develop and evaluate a 180-day infection quality metric.

Methods: This study evaluated Medicare claims that were merged with institutional Society of Thoracic Surgeons Adult Cardiac Surgery Database files among patients undergoing cardiac surgery across 33 Michigan centers. The primary outcome was an infection within 180 days of surgery.

DESCRIPTION OF THE CLINICAL AND RADIOLOGICAL CHARACTERISTICS OF PULMONARY EMBOLISM IN COVID-19 VERSUS NON COVID-19 PATIENTS: A MULTICENTRIC CROSS-SECTIONAL STUDY OVER A 24-MONTH PERSPECTIVE.

Background: COVID-19 is associated with intense systemic inflammation and abnormal coagulation profile leading to an increased incidence of pulmonary embolism (PE). This study investigates whether PE in COVID-19 patients has different clinical, laboratory and radiological characteristics when compared to traditional PE in COVID negative patients.

Methods: We conducted an observational, multicentric, cross-sectional study on consecutive patients diagnosed with PE at admission or during hospital stay from February 21 2019 to February 20 2021.

Ethnicity-specific patterns of epigenetic age acceleration in rheumatoid arthritis.

Rheumatoid arthritis (RA) is an age-related chronic inflammatory disease which may include accelerated biological ageing processes in its pathogenesis. To determine if increased biological age is associated with risk of RA and/or is present once disease is established. We used DNA methylation to compare biological age (epigenetic age) of immune cells in adults at risk of RA and those with confirmed RA, including twins discordant for RA.

Efficacy and Safety of Polatuzumab-Vedotin plus Bendamustine and Rituximab in patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Systematic Review and Meta-Analysis.

Background: Diffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin's lymphoma subtype, relapses or becomes refractory (R/R) in 40% of cases after initial treatment. Among the second-line treatments for these patients is CAR T-cell therapy, which is considered the gold standard and treatment better than SCT. For these patients, polatuzumab vedotin in combination with bendamustine and rituximab (Pola-BR) is a novel treatment.

Shifting temporal trends and disparities in sarcoidosis mortality in the United States: A retrospective analysis from 1999 to 2020.

Introduction: Sarcoidosis is an inflammatory disease characterized by granulomas, the etiology of which remains unclear. This study examines sarcoidosis-related mortality trends in the United States from 1999 to 2020, with a focus on disparities pertaining to patient sex, geographical location, and urbanization status.

Methods: We analyzed death certificate data from the CDC WONDER database, using ICD-10 code D86.

Assessing health systems' capacities to provide post-abortion care: insights from seven low- and middle-income countries.

Background: Abortion-related complications significantly contribute to maternal morbidity and mortality globally. Post-abortion care (PAC) services are essential to safeguarding women's rights by substantially mitigating the health risks associated with abortions - a step which is fundamental to achieving reproductive and maternal health-related Sustainable Development Goals.

Methods: We conducted a secondary analysis of data from the nationally representative Service Provision Assessment (SPA) surveys conducted between 2015 and 2024 across three regions in seven low- and middle-income countries: Afghanistan, Bangladesh, Nepal, the Democratic Republic of Congo (DRC), Ethiopia, Senegal, and Haiti.

Environmental applications of metal-organic framework-based three-dimensional macrostructures: a review.

Metal-organic frameworks (MOFs) hold considerable promise for environmental remediation owing to their exceptional performance and distinctive structure. Nonetheless, the practical implementation of MOFs encounters persistent technical hurdles, notably susceptibility to loss, challenging recovery, and potential environmental toxicity arising from the fragility, insolubility, and poor processability of MOFs. MOF-based three-dimensional macrostructures (3DMs) inherit the advantageous attributes of the original MOFs, such as ultra-high specific surface area, tunable pore size, and customizable structure, while also incorporating the intriguing characteristics of bulk materials, including hierarchical structure, facile manipulation, and structural flexibility.

Hemizygous Moesin (MSN) Gene Deletion in an Adult With Chronic Neutropenia.

X-linked moesin-associated immunodeficiency (X-MAID) is a recently identified combined immunodeficiency caused by a mutation in the moesin () gene. It is characterized by cytopenias, hypogammaglobulinemia, poor immune response to vaccine antigens, and increased susceptibility to early-life infections. We report a patient with adult-onset neutropenia, lymphopenia, inadequate response to the pneumococcal polysaccharide vaccine (PPSV23), and recurrent bacterial infections associated with a hemizygous deletion.

Serum Insulin, Insulin-Like Growth Factor-1, Testosterone and Lipid Profile Levels in Benign Prostatic Hyperplasia and Prostate Cancer at Diagnosis.

Background And Objectives: Prostate cancer is the second most frequently diagnosed cancer in men aged 65 years and older globally. The association of prostate cancer with deranged lipid profile and insulin levels is inconsistent and not well understood. This study aimed to analyze the serum levels of lipids, insulin, insulin-like growth factor-1 (IGF-1) and testosterone and to identify their association with the risk of benign prostatic hyperplasia, prostate cancer and its grading.

Nanocellulose extraction from date palm waste using 1-butyl-3-methylimidazolium hydrogen sulphate.

This study provides insights into nanocellulose production using 1-butyl-3-methylimidazolium hydrogen sulphate ([Bmim]HSO) as a green solvent, utilizing cellulose derived from date palm waste. Critical hydrolysis parameters were optimized through analysis of variance and response surface methodology. The predicted nanocellulose yield (Y) followed a quadric equation represented by Y=55.

Prevalence and histopathological analysis of cystic echinococcosis in ruminants of District Narowal, Pakistan: focus on pulmonary involvement.

A total of 384 animals (sheep, goat, cattle, and buffalo) were examined for the presence of hydatid cysts only in the lungs. The lung tissue samples associated with the hydatid cyst were collected immediately after slaughter, followed by fixation in 10% formalin. The fixed tissue was subjected to paraffin embedding technique.

Novel deep neural network architecture fusion to simultaneously predict short-term and long-term energy consumption.

Energy is integral to the socio-economic development of every country. This development leads to a rapid increase in the demand for energy consumption. However, due to the constraints and costs associated with energy generation resources, it has become crucial for both energy generation companies and consumers to predict energy consumption well in advance.

Evaluating the reliability of a microperimetry-based method for assessing visual function in the junctional zone of geographic atrophy lesions.

Purpose: To assess the repeatability of a microperimetry methodology for quantifying visual function changes in the junctional zone of eyes with geographic atrophy (GA) in the clinical trial context.

Methods: A post hoc analysis of the OAKS phase III trial was conducted, which enrolled patients with GA secondary to age-related macular degeneration. Microperimetry using a standard 10 - 2 fovea centered grid was performed at baseline and follow-up visits.

Associations between paraoxonase-1 activity and therapeutic drug monitoring indicators in schizophrenia patients treated with olanzapine: A cross-sectional study.

Objective: Therapeutic drug monitoring (TDM) indicators have been suggested to predict overall outcome responses to olanzapine (OLZ) treatments in terms of efficacy and metabolic syndrome. This study aimed to investigate whether paraoxonase-1 (PON-1) activity can be used to predict schizophrenia patient outcomes.

Methods: Schizophrenic patients ( = 50) aged between 20 and 65 years who received OLZ treatment were recruited, and their Positive and Negative Syndrome Scale scores, PON-1 activity, and olanzapine drug levels normalized by dose (OLZ/D) and its metabolite N-desmethyl-olanzapine (DMO), together with biochemical parameters, were determined.

Prevalence of Musculoskeletal Disorders in Heavy Vehicle Drivers and Office Workers: A Comparative Analysis Using a Machine Learning Approach.

: Job profiles such as heavy vehicle drivers and transportation office workers that involve prolonged static and inappropriate postures and forceful exertions often impact an individual's health, leading to various disorders, most commonly musculoskeletal disorders (MSDs). In the present study, various individual risk factors, such as age, weight, height, BMI, sleep patterns, work experience, smoking status, and alcohol intake, were undertaken to see their influence on MSDs. The modified version of the Nordic Questionnaire was administered in the present cross-sectional study to collect data from 48 heavy vehicle drivers and 40 transportation office workers.