Copper and the synthesis of elastin and collagen.

Copper's role in connective tissue is linked to the enzyme lysyl oxidase. From a biochemical perspective, copper is a cofactor for the enzyme and a determinant of its activity in connective tissues. Lysyl oxidase catalyses a post-translational oxidation of certain lysine and hydroxylysine residues.

Clinical and pathological observations on field and experimental zoalene poisoning in broiler chicks and the effect of the drug on laying hens.

Depression and ataxia was seen in 24-day-old chicks accidentally fed excess zoalene from 14 days of age. The presence of a small amount of furazolidone in the ration probably exacerbated the effect. There were no deaths.