Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus.

Aims: Chromium (Cr) is a trace element involved in glucose homeostasis. We aim to evaluate and quantify the effects of Cr supplementation on A1C and FPG in patients with T2DM.

Materials And Methods: A systematic literature search of Pubmed, EMBASE and the Cochrane Library (from database inception to 11/2014) with no language restrictions sought RCTs or cohort studies evaluating Cr supplementation in T2DM vs control and reporting either change in glycated hemoglobin (A1C) or fasting plasma glucose (FPG).

Increased risk for atypical fractures associated with bisphosphonate use.

Background: Studies suggest an increasing occurrence of atypical femoral fractures with the use of bisphosphonates.

Objective: To examine whether the use of bisphosphonates increases the risk for atypical fractures.

Design: Systematic review and meta-analysis.