Publications by authors named "Raymundo Garcia"
Background: MK-0616 is an oral macrocyclic peptide inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) in development for the treatment of hypercholesterolemia.
Objectives: This Phase 2b, randomized, double-blind, placebo-controlled, multicenter trial aimed to evaluate the efficacy and safety of MK-0616 in participants with hypercholesterolemia.
Methods: This trial was planned to include 375 adult participants with a wide range of atherosclerotic cardiovascular disease risk.
Objective: To assess the efficacy and safety of sitagliptin in youth with type 2 diabetes (T2D) inadequately controlled with metformin ± insulin.
Study Design: Data were pooled from two 54-week, double-blind, randomized, placebo-controlled studies of sitagliptin 100 mg daily or placebo added onto treatment of 10- to 17-year-old youth with T2D and inadequate glycemic control on metformin ± insulin. Participants (N = 220 randomized and treated) had HbA1c 6.
Objective: To assess the efficacy and safety of DPP-4 inhibition with sitagliptin in youth with type 2 diabetes (T2D).
Study Design: This was a 54-week, double-blind, randomized, controlled clinical trial evaluating the safety and efficacy of DPP-4 inhibition with sitagliptin 100 mg once daily as initial oral therapy in youth with T2D. The 190 participants, aged 10-17 years, had HbA1c 6.
[Microorganisms in the biological control of insects and phytopathogens].
Rev Latinoam Microbiol
September 2007
Article Synopsis
- The review discusses the use of microorganisms, such as bacteria, viruses, and fungi, as biological control agents for pests and diseases affecting crops.
- The document details how these microorganisms work to combat insects and plant diseases, outlining their modes of action.
- Additionally, it introduces innovative strategies to enhance the effectiveness of these biological controls and describes the development of various formulations intended for field applications.