Immunomodulatory Nanoparticles Induce Autophagy in Macrophages and Reduce Burden in the Lungs of Mice.

Tuberculosis (TB) is the leading cause of death from infectious disease. Macrophages are the primary immune responders and become the primary host cells for the causative agent . Following the uptake of , the inherent antimicrobial action of macrophages is dampened, enabling the bacterium to reside within these cells and multiply.

Mycobacterium Tuberculosis and Interactions with the Host Immune System: Opportunities for Nanoparticle Based Immunotherapeutics and Vaccines.

Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a deadly infectious disease. The thin pipeline of new drugs for TB, the ineffectiveness in adults of the only vaccine available, i.e.