Effect of particle shape on dry particle inhalation: study of flowability, aerosolization, and deposition properties.

The shape effects of dry particles on flowability, aerosolization, and deposition properties in inhalation drug delivery are studied. The properties are compared with similar size range particles of different shapes such as sphere, needle, cube, plate, and pollen. Flowability of the particles is characterized by Carr's compressibility index and angle of slide (theta) method.

Minimum detectable change in water diffusion using 3-T magnetic resonance imaging.

The objective of this study was to determine the minimum change in fractional anisotropy (FA), mean diffusivity (MD), and transverse diffusivity (TD) that can be detected in a repeated diffusion tensor imaging (DTI) session with 95% confidence, i.e., the minimum detectable change (MDC).