L-tyrosine production by recombinant Escherichia coli: fermentation optimization and recovery.

L-tyrosine (L-tyr) overproducing Escherichia coli strain derived from an L-phenylalanine (L-phe) overproducing strain is characterized in 10 L and 200 L scale fermentations. Deletion of the chromosomal region encoding for the pheA gene, chorismate mutase/prephenate dehydratase, its leader peptide (pheL) and its associated promoter resulted in significant increase in L-tyr production (Olson et al., 2007.