Pseudomelanocytic nests mimicking atypical melanocytic proliferations: first reported cases in the oral cavity.

The concept of pseudomelanocytic nests has been recently described in the dermatology literature. To our knowledge, this entity has yet to be published in the oral pathology literature. We report 2 cases with features of pseudomelanocytic nests.

Malignant epithelioid hemangioendothelioma of the lip: a case report and comprehensive literature review.

Malignant epithelioid hemangioendothelioma (MEH), also known as high-risk epithelioid hemangioendothelioma, is a low- to intermediate-grade vascular malignancy originally described as a vascular neoplasm of endothelial origin. This very rare vascular neoplasm has been described mainly in soft tissue, but also in various organs and locations, including the liver, lung, brain, colon, lymph nodes, peritoneum, spleen, bone, skin, heart, soft tissues, and vascular system. Several cases have been described in the head and neck, including the submandibular gland, parotid gland, nasal cavity, parapharyngeal space, maxilla, maxillary sinus, occipital bone, oral cavity, thyroid gland, neck, scalp, larynx, and mandible.

Bowman birk inhibitor concentrate and oral leukoplakia: a randomized phase IIb trial.

Oral premalignancy serves as an ideal model for study of chemopreventive agents. Although 13-cis-retinoic acid showed reversal of oral premalignancy, toxicity, and reversal of clinical response after cessation of therapy obviated its widespread use. A search for nontoxic agents with cancer preventive activity led us to evaluate Bowman Birk Inhibitor (BBI) formulated as BBI Concentrate (BBIC).

Failure to diagnose pathology: an avoidable complication in oral and maxillofacial surgery.

The routine submission of abnormal tissue for histopathologic diagnosis is a vital link in the appropriate management of patients. Receipt of a biopsy report brings the usual case to its full conclusion. Patients are best served when clinical impressions are verified by histopathologic examination, and this in turn will reduce the likelihood of successful malpractice litigation for failure or delay in diagnosis.

Estrogen and progesterone receptor and p53 gene expression in adenoid cystic cancer.

Objectives: The current study examined the role of estrogen receptors (ER), progesterone receptors (PR) and p53 expression in adenoid cystic carcinoma (ACC) to determine if simple expression or possible overexpression of these products might influence the development and natural course of this cancer.

Study Design: ER and PR status and p53 overexpression were retrospectively evaluated utilizing immunohistochemical evaluation of 47 ACC specimens.

Methods: Formalin-fixed paraffin-embedded tissues from 47 ACC specimens and 47 samples of normal salivary gland tissue were evaluated histochemically for the presence of ER, PR and p53.

The use of biopsy in dental practice. The position of the American Academy of Oral and Maxillofacial Pathology.

Biopsy is the gold standard of diagnostic procedures. The American Academy of Oral and Maxillofacial Pathology has stated its position concerning biopsy use in dental practice, believing that using the procedure more frequently will enhance diagnosis and contribute substantially to the quest for more evidence-based practice. Biopsy is a technique within the scope of practice of general dentists.