Phenotypic Profile of -Specific CD4 T-Cell Responses in People With Advanced Human Immunodeficiency Virus Who Develop Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

Background: Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a frequent complication of cotreatment for TB and human immunodeficiency virus (HIV)-1. We characterized (Mtb)-specific CD4 T-cell phenotype and transcription factor profile associated with the development of TB-IRIS.

Methods: We examined the role of CD4 T-cell transcription factors in a murine model of mycobacterial IRIS.