Small cell carcinoma of unknown primary.

Small cell carcinoma of unknown primary (SCUP) is an uncommon cancer that is usually diagnosed in the lymph nodes, liver, brain, or bone. Historically, this neoplasm has always been included with extrapulmonary small cell carcinomas (EPSCCs). The true incidence of SCUP is unknown but has been reported to comprise between 7% and 30% of EPSCCs.

Cardiotoxicity of cancer therapy.

Because cancer is a leading cause of mortality in the United States, the number of therapeutic modalities available for the treatment of neoplastic processes has increased. This has resulted in a large number of patients being exposed to a wide variety of cancer therapy. Historically, it has been well recognized that antineoplastic agents may have adverse effects on multiple organs and normal tissues.