Publications by authors named "Raymond A. Firestone"
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Synopsis of recent research by authors named "Raymond A. Firestone"
- Raymond A. Firestone's recent research focuses on developing and evaluating novel cancer therapies, particularly peptide-doxorubicin (PDOX) prodrugs, which aim to enhance efficacy while minimizing toxic side effects in various cancer models, including gastric and breast cancers.
- Key findings from his studies include evidence of significant tumor growth inhibition with PDOX compared to standard doxorubicin, along with insights into the mechanisms of action, such as lysosomal membrane permeabilization and mitochondrial damage in cancer cells.
- His work also emphasizes the potential for targeted therapies using cathepsin B-cleavable prodrugs, which have shown promise in preclinical models by reducing systemic toxicity while maintaining therapeutic effectiveness against metastatic cancers.
