Publications by authors named "Raymond A Firestone"
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Synopsis of recent research by authors named "Raymond A Firestone"
Recent research by Raymond A. Firestone focuses on developing innovative doxorubicin prodrugs, such as peptide-doxorubicin (PDOX), to enhance anticancer efficacy while minimizing toxicity in various cancer models, notably gastric and breast cancers.
His studies reveal that PDOX demonstrates significant tumor-inhibitory effects compared to traditional doxorubicin, with promising results in both in vitro and in vivo settings.
Additionally, Firestone's work explores the synergistic effects of combining lysosomal membrane permeabilization with glycolysis inhibition, elucidating new mechanisms of action that contribute to effective cancer cell death without harming normal cells.
