Publications by authors named "Rayleigh Chan"
Introduction: The burn treatment room at our tertiary-care centre is run by a multidisciplinary team, providing care to primarily burn patients who require moderate to deep sedation to undergo dressing changes in a monitored setting outside the operating room. There is little literature on the safety, efficacy, and logistics of treating outpatient pediatric burn patients in this manner. This study reviews the safety of deep sedation in the burn treatment room.
View Article and Find Full Text PDFMarfan syndrome (MFS) is a genetic disorder that frequently leads to aortic root dissection and aneurysm. Despite promising preclinical and pilot clinical data, a recent large-scale study using antihypertensive angiotensin II (AngII) receptor type 1 (ATR1) blocker losartan has failed to meet expectations at preventing MFS-associated aortic root dilation, casting doubts about optimal therapy. To study the deleterious role of normal ATR1 signaling in aortic root widening, we generated MFS mice lacking ATR1a expression in an attempt to preserve protective ATR2 signaling.
View Article and Find Full Text PDFArticle Synopsis
- Dysferlinopathies, such as limb-girdle muscular dystrophy type 2B and Miyoshi myopathy, are characterized by progressive muscle atrophy and loss of mobility, but animal models like dysferlin-null mice show less severe symptoms than humans.
- A new study created a double-knockout mouse model (DysfApoE) to explore the impact of vascular disease, finding that these mice developed severe mobility issues and significant muscle damage by 11 months.
- The research suggests that high cholesterol levels could harm muscle health in dysferlinopathies and that differences in how mice and humans handle lipids might influence the severity of the condition.