Publications by authors named "Rayan Hajjar"
In clear cell renal cell carcinoma (ccRCC), the von Hippel-Lindau tumor suppressor gene/hypoxia inducible factor (VHL/HIF) axis lays the groundwork for tumorigenesis and is the target of many therapeutic agents. HIF activation alone, however, is largely insufficient for kidney tumor development, and secondary mutations in , , , , or other tumor suppressor genes are strong enablers of tumorigenesis. Interestingly, it has been discovered that VHL loss and subsequent HIF activation results in upregulation of a negative feedback loop mediated by ISGF3, a transcription factor activated by type I interferon (IFN).
View Article and Find Full Text PDFBRCA1-associated protein 1 (BAP1) is a deubiquitinase that is mutated in 10-15% of clear cell renal cell carcinomas (ccRCC). Despite the association between BAP1 loss and poor clinical outcome, the critical tumor suppressor function(s) of BAP1 in ccRCC remains unclear. Previously, we found that hypoxia-inducible factor 2α (HIF2α) and BAP1 activate interferon-stimulated gene factor 3 (ISGF3), a transcription factor activated by type I interferons and a tumor suppressor in ccRCC xenograft models.
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- Carbapenem resistance is a growing global health issue, making it harder to treat infections from hospital-acquired pathogens.
- New carbapenemase inhibitors, including avibactam, relebactam, and vaborbactam, show promise in combating this resistance.
- The review highlights recent advancements in these inhibitors, particularly focusing on β-lactam/β-lactamase inhibitor combinations that could effectively tackle infections caused by resistant pathogens.
Objective: COVID-19 has caused a massive surge in telemedicine utilization as patients and physicians tried to minimize in-person contact to avoid the spread and impact of the pandemic. This study aims to expand on the knowledge of telemedicine during and beyond the COVID-19 era as it pertains to its use, efficacy, and patient and provider satisfaction through surveys.
Methods: This is a retrospective study involving 93 patients and 33 Neurosurgery physicians who anonymously participated in the survey about their experience with telemedicine visits.
Background: The anterior communicating artery (AcoA) is the most common location for intracranial aneurysms.
Objective: To present occlusion outcomes, complication rate, recurrence rate, and predictors of recurrence in a large cohort with AcoA aneurysms treated primarily with endosaccular embolization. We also attempt to present data on the most effective treatment modality for recurrent AcoA aneurysms.
Glioblastoma Multiforme (GBM) is the most common primary central nervous system (CNS) malignancy in adults. It is very aggressive and is notorious for its fast and local invasion of nearby brain parenchyma. Consequently, the overall survival (OS) of patients with GBM is short despite resection, radiotherapy and chemotherapy regimens.
View Article and Find Full Text PDFThe treatment of orbital lymphaticovenous malformations (OLVMs) has evolved from simple surgical resection to a multimodal approach consisting of sclerosing agents, embolization, and resection depending on the specific components that compose the lesion. Here we present a representative case series of 5 nonconsecutive patients who underwent percutaneous embolization of OLVMs with the Onyx Liquid Embolic System (Medtronic, Dublin, Ireland) before surgical resection between 2019 and 2021. OLVMs are rare, benign, congenital lesions that grow with age and can become symptomatic and disabling.
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- Arcanobacterium haemolyticum is a rare but significant cause of pharyngotonsillitis in children and young adults, often not detected due to lack of routine testing, with limited information on its complications and treatment.
- A systematic review of literature identified 17 relevant studies involving 191 patients, showing that throat pain was the most common symptom and that diagnosis is largely confirmed through positive cultures from pharyngeal swabs.
- The review indicates that most cases respond well to penicillin, emphasizes the potential for serious complications, and proposes a management algorithm to enhance diagnosis and treatment.
Article Synopsis
- The text is a correction to a previously published article, identified by its DOI: 10.3389/fonc.2020.609100.
- Corrections typically address errors in the original publication, which could involve data, methodology, or other essential details.
- This highlights the importance of accuracy and transparency in scientific literature for the community's understanding and future research.
Article Synopsis
- Recent advances in breast cancer research have led to the increased use of genomic assays, which personalize treatment and help manage the disease more effectively.
- Genomic tests help assess the risk of cancer recurrence in early-stage patients and can guide treatment choices to reduce unnecessary side effects.
- This article focuses on the application of genomic tests in node positive breast cancer, discussing their impact on chemotherapy decisions and reviewing current studies and guidelines.
Background: Our objective was to identify published models of coordination between entities funding or delivering health services in humanitarian crises, whether the coordination took place during or after the crises.
Methods: We included reports describing models of coordination in sufficient detail to allow reproducibility. We also included reports describing implementation of identified models, as case studies.