Publications by authors named "Ray Yurko"
Background: Amiodarone is underutilized due to significant off-target toxicities. We hypothesized that targeted delivery to the heart would lead to the lowering of the dose by utilizing a cardiomyocyte-targeting peptide (CTP), a cell-penetrating peptide identified by our prior phage display work.
Methods: CTP was synthesized thiolated at the N-terminus, conjugated to amiodarone via Schiff base chemistry, HPLC purified, and confirmed with MALDI/TOF.
Article Synopsis
- Modern medicine has greatly improved life expectancy and quality of life with various therapeutic drugs, but many of these drugs come with serious side effects.
- Amiodarone, a popular drug for treating cardiac arrhythmia, also has significant systemic side effects when used long-term.
- This article discusses a next-generation prodrug version of amiodarone that uses a specialized peptide to target heart cells more efficiently, showing promising results in guinea pigs where it appears effective at a much lower dose.
Background: Amiodarone is underutilized due to significant off-target toxicities. We hypothesized that targeted delivery to the heart would lead to lowering of dose by utilizing a cardiomyocyte targeting peptide (CTP), a cell penetrating peptide identified by our prior phage display work.
Methods: CTP was synthesized thiolated at the N-terminus, conjugated to amiodarone via Schiff base chemistry, HPLC purified and confirmed with MALDI/TOF.