[A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy].

Hematopoiesis is orchestrated by a succession of lineage- and stage-specific transcription factors working in concert with chromatin modifiers. Here, we explored the role of KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofactor KAP1 in this process. The hematopoietic-restricted deletion of Kap1 in the mouse resulted in severe hypoproliferative anemia, with Kap1-deleted erythroblasts failing to induce mitophagy-associated genes, hence to eliminate mitochondria.

A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy.

During hematopoiesis, lineage- and stage-specific transcription factors work in concert with chromatin modifiers to direct the differentiation of all blood cells. We explored the role of KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofactor KAP1 in this process. In mice, hematopoietic-restricted deletion of Kap1 resulted in severe hypoproliferative anemia.