Publications by authors named "Ray Fukuoka"
Article Synopsis
- - Canine gastrointestinal lymphoma is mostly T-cell in origin, but the genetic details aren't fully understood.
- - Previous studies in humans show mutations in genes linked to the JAK-STAT pathway, which are crucial for signaling in immune responses.
- - In this study of 31 dogs, only a few mutations were found in the STAT3 and JAK1 genes, and there wasn't a strong link between these mutations and large cell gastrointestinal lymphoma in dogs.
L-Asparaginase (L-Asp) is often used to induce remission in feline large-cell gastrointestinal lymphoma (LCGIL). However, no study has evaluated the efficacy and adverse events following the initial use of this drug as a first-line treatment in feline LCGIL. We retrospectively reviewed medical records of cats with LCGIL treated with L-Asp to induce remission.
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- - The study investigates the gene expression profiles of dogs with high-grade B-cell lymphoma who underwent chemotherapy, focusing on those that either relapsed early or achieved remission.
- - Researchers analyzed 25 cases and identified 179 differentially expressed genes (DEGs), highlighting specific genes related to immune signaling and tumor interactions that differed between dogs that relapsed and those that did not.
- - Notably, genes like CCL4 were downregulated in the relapse group, while genes such as CD3E, ITK, and LAT were upregulated, suggesting that tumor and immune cell interactions play a crucial role in the effectiveness of chemotherapy.