A Focal Impact Model of Traumatic Brain Injury in Tadpoles Reveals Behavioral Alterations, Neuroinflammation, and an Astroglial Response.

Traumatic Brain Injury (TBI) is a global driver of disability, and we currently lack effective therapies to promote neural repair and recovery. TBI is characterized by an initial insult, followed by a secondary injury cascade, including inflammation, excitotoxicity, and glial cellular response. This cascade incorporates molecular mechanisms that represent potential targets of therapeutic intervention.