Association of and Gene Polymorphism in Arab Women with and without Osteoporosis.

Receptor activator of the nuclear factor-κB ligand (RANKL) and osteoprotegerin genes (OPG) were identified as susceptible loci for postmenopausal osteoporosis (PMO) in various ethnicities, but neither have been studied in an Arabian population. Hence, the current study aimed to fill this gap. A total of 372 postmenopausal women (174 osteoporosis (OP) and 198 control group (CTRs)) were genotyped for four SNPs: rs2277438A/G and rs9533156T/C (), and rs2073618C/G and rs3102735T/C ().

Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women.

The RANKL/RANK/OPG pathway regulates bone remodelling and turnover. However, the genetic background of bone mineral density (BMD) and osteopenia in Saudi postmenopausal women is yet to be studied. We studied the genetic polymorphism of with BMD and other associated factors in Saudi postmenopausal osteopenic women.