Publications by authors named "Ravit Cohen-Segev"
Article Synopsis
- Congestive heart failure (CHF) negatively impacts kidney function, with the activation of the renin-angiotensin-aldosterone system (RAAS) leading to issues like salt/water retention and cardiac hypertrophy.
- In a study on rats, acute administration of angiotensin 1-7 (Ang 1-7) showed positive effects on kidney function parameters like urinary flow and filtration rates, especially in non-CHF rats.
- Chronic treatment with Ang 1-7 significantly improved kidney function and reduced cardiac hypertrophy in CHF rats, suggesting it could be a potential therapeutic agent for managing CHF-related complications.
Congestive heart failure is often associated with impaired kidney function. Over-activation of the renin-angiotensin-aldosterone system (RAAS) contributes to avid salt and water retention in heart failure. While the expression of angiotensin converting enzyme (ACE), a key enzyme in the synthesis of angiotensin II (Ang II), is well established, the expression of angiotensin converting enzyme-2 (ACE-2), an enzyme responsible for angiotensin 1-7 generation, is largely unknown.
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