Curcumin attenuates replicative senescence in human dental follicle cells and restores their osteogenic differentiation.

Objective: This study aimed to examine the therapeutic effects of curcumin against replicative senescence in dental follicle cells (DFCs).

Methods: Human DFCs were cultured in Dulbecco's Modified Eagle Medium with growth supplements. Replicative senescence in DFCs at different passages was assessed using β-galactosidase activity assay.