Production, Characterization and Evaluation of Kaempferol Nanosuspension for Improving Oral Bioavailability.

Context: Kaempferol has a large particle size and poor water solubility, leading to poor oral bioavailability. The present work aimed to develop a kaempferol nanosuspension (KNS) to improve pharmacokinetics and absolute bioavailability.

Methods: A nanosuspension was prepared using high pressure homogenization (HPH) techniques.