Metal nanoparticles as inhibitors of enzymes and toxins of multidrug-resistant .

is an aerobic Gram-positive spherical bacterium known to cause a broad range of infections worldwide. It is a major cause of infective skin and soft infections and severe and life-threatening conditions, such as pneumonia, bloodstream infections, and endocarditis. The emergence of drug-resistant strains of , particularly methicillin-resistant (MRSA), has become a significant concern in the healthcare community.

Optimization of vertically aligned carbon nanotube beam trajectory with the help of focusing electrode in the microchannel plate.

The focusing electrode plays an important role to reduce the electron beam trajectory with low dispersion and high brightness. This article summarizes the importance of the vertically aligned multi-walled carbon nanotube effect with the focusing electrode. First of all, the effect of electron beam trajectory is studied with the different heights, hole sizes, and applied voltage of the focusing electrode by the opera 3D simulation.

Feasibility, Sustainability, and Effectiveness of the Implementation of "Facility-Team-Driven" Approach for Improving the Quality of Newborn Care in South India.

Objectives: The primary objective of the study was to assess the feasibility and sustainability of the implementation of the point of care quality improvement (POCQI) methodology for improving the quality of neonatal care at the level 2 special newborn care unit (SNCU). Additional objective was to evaluate the effectiveness of the quality improvement (QI) and preterm baby package training model.

Methods: This study was conducted in a level-II SNCU.

S-BIRD: A Novel Critical Multi-Class Imagery Dataset for Sewer Monitoring and Maintenance Systems.

Computer vision in consideration of automated and robotic systems has come up as a steady and robust platform in sewer maintenance and cleaning tasks. The AI revolution has enhanced the ability of computer vision and is being used to detect problems with underground sewer pipes, such as blockages and damages. A large amount of appropriate, validated, and labeled imagery data is always a key requirement for learning AI-based detection models to generate the desired outcomes.

Genome-wide association mapping for component traits of drought and heat tolerance in wheat.

Identification of marker trait association is a prerequisite for marker-assisted breeding. To find markers linked with traits under heat and drought stress in bread wheat ( L.), we performed a genome-wide association study (GWAS).

Lipid- and TPGS-Based Core-Shell-Type Nanocapsules Endowed with High Paclitaxel Loading and Enhanced Anticancer Potential.

The current study elucidates the improved drug loading of paclitaxel (PTX) in lipid- and D-α-tocopheryl polyethylene glycol succinate (TPGS)-based core-shell-type lipid nanocapsules (PTX-TPGS-LNC) for augmenting the therapeutic efficacy and curbing the toxicity. PTX-TPGS-LNCs were formulated by employing anti-solvent precipitation technique and displayed a particle size of 162.1 ± 4.

-Derived Phytopharmaceutical Drug Has Potent Anti-dengue Activity.

Dengue is a serious public health concern worldwide, with ∼3 billion people at risk of contracting dengue virus (DENV) infections, with some suffering severe consequences of disease and leading to death. Currently, there is no broad use vaccine or drug available for the prevention or treatment of dengue, which leaves only anti-mosquito strategies to combat the dengue menace. The present study is an extension of our earlier study aimed at determining the and protective effects of a plant-derived phytopharmaceutical drug for the treatment of dengue.

Differential Physiological Prerequisites and Gene Expression Profiles of Conidial Anastomosis Tube and Germ Tube Formation in .

The conidia of a hemibiotrophic fungus, , can conventionally form a germ tube (GT) and develop into a fungal colony. Under certain conditions, they tend to get connected through a conidial anastomosis tube (CAT) to share the nutrients. CAT fusion is believed to be responsible for the generation of genetic variations in few asexual fungi, which appears problematic for effective fungal disease management.

Inhibitory kinetics and mechanism of pentacyclic triterpenoid from endophytic Colletotrichum gigasporum against pancreatic lipase.

The burden of obesity is increasing all over the world. Except for Orlistat, no effective anti-obesity drug is currently available. Therefore, a search for the new anti-obesity compound is need of time.

Data on the inhibitory effect of endophytic fungi of traditional medicinal plants against pancreatic lipase (PL).

This article describes isolation and pancreatic lipase (PL) inhibitory potential of 18 endophytic fungi isolated from the various parts of six indigenous medicinal plants. PL catalyzes absorption and hydrolysis of triglycerides into di-glycerides into mono-glycerides and free fatty acids. PL inhibitors are well-known for the disruption of pancreatic lipase activity.

Factors influencing the gut microbiome in children: from infancy to childhood.

The human microbiota plays a crucial role in educating the immune system and influencing host health right since birth. Various maternal factors along with the vertical microbial transfer from the mother, as well as the horizontal environmental transmission and internal factors relating to the infant, play a crucial role in modulating the gut microbiota. The early life microflora is highly unstable and undergoes dynamic changes during the first few years, converging towards a more stabilized adult microbiota by co-evolving with the host by the age of 3-4 years.

Determination of Iron Chelating Agents by Analytical Methods: A Review.

Acute iron poisoning and chronic iron overload consequences in significant morbidity and mortality worldwide. Treatment of acute iron poisoning and chronic iron overload can be challenging and care providers are often tackled with management dilemmas. Iron chelating agents are commonly prescribed for patients with iron deficiency anemia.

Design and Toxicity Evaluation of Novel Fatty Acid-Amino Acid-Based Biocompatible Surfactants.

Surfactants occupy an important place owing to their wide application, but primarily compromised due to its toxicity issues. This raises the need for exploration of newer surfactants with increased biocompatibility. Novel fatty acid- and amino acid-based surfactants were prepared using standard carbodiimide chemistry.

Steroidal fraction of Carissa carandas L. inhibits microbial hyaluronidase activity by mixed inhibition mechanism.

Hyaluronidase (hyase) is a hyaluronic acid (HA) depolymerizing enzyme produced by many pathogenic bacteria as a virulence factor to establish and spread infections. Present studies established that a steroidal fraction (SF) isolated from leaves of Carissa carandas act as a strong hyase inhibitor. The kinetic parameters involved in the inhibition of hyase by purified SF were studied and compared with standard hyase inhibitor quercetin.

Squamous papilloma of the renal pelvis mimicking transitional cell carcinoma.

Squamous papilloma of the renal pelvis is an extremely rare entity. To the best of our knowledge, no case has been reported till date. A 45-year-old female presented to us with flank pain for two months.

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review.

The family Apocynaceae is one of the largest and important families in angiosperm. Several members of this family have medicinal properties and have been in the treatment of various ailments. Most of them are consumed as food by tribal people whereas a few plants are used as source of poison.

ISATIN: New Hope Against Convulsion.

Background: Epilepsy is one in every of the foremost important chronic neurological disorders with high incidence worldwide. Several epileptic patients don't seem to be fully treated with currently available marketed medicines likewise so many drugs have shown unfavorable side effect and drug interaction. Therefore, there are continuing interests to seek out new anticonvulsant drugs.

Predictive modeling for corrective maintenance of imaging devices from machine logs.

In the cost sensitive healthcare industry, an unplanned downtime of diagnostic and therapy imaging devices can be a burden on the financials of both the hospitals as well as the original equipment manufacturers (OEMs). In the current era of connectivity, it is easier to get these devices connected to a standard monitoring station. Once the system is connected, OEMs can monitor the health of these devices remotely and take corrective actions by providing preventive maintenance thereby avoiding major unplanned downtime.

Antiasthmatic related properties of leaves on various models.

Objective: Asthma is a multifaceted inflammatory disorder which results into narrowing of airway with broncho-constriction and spasm. As the complex pathophysilogy of asthma, various animal models are generally used to investigate the immunological and physiological pathogenesis of disease. Linn (Fabacease) is a climbing shrub.

A cross-sectional comparative study of gut bacterial community of Indian and Finnish children.

The human gut microbiome plays a crucial role in the compositional development of gut microbiota. Though well documented in western pediatrics population, little is known about how various host conditions affect populations in different geographic locations such as the Indian subcontinent. Given the impact of distinct environmental conditions, our study assess the gut bacterial diversity of a small cohort of Indian and Finnish children and investigated the influence of FUT2 secretor status and birth mode on the gut microbiome of these populations.

An analytics based clinical decision support system for CVD risk assessment and management.

Cardiovascular disease (CVD) is a major cause of disability and premature death throughout the world. Acute coronary events and other cardiovascular events frequently occur suddenly, and are often fatal before medical care can be given. Risk factor modification can reduce clinical events and premature death in people with established cardiovascular disease as well as in those who are at high cardiovascular risk due to one or more risk factors.

A method to detect tortuosity of vessel using non imaging ultrasound approach in carotid structure.

Stroke is a leading cause of functional impairments. The typical screening mechanism is to measure localized Peak Systolic Velocity (PSV) and diagnose impending risk associated with stoke by characterizing the PSV values. However, an accurate measurement of PSV using Doppler ultrasound is affected due to the tortuous nature of carotid artery in elder population group as the angle at which acoustic beam strikes the vessel is over or under estimated resulting in improper measure the blood flow velocity.

A machine learning framework for auto classification of imaging system exams in hospital setting for utilization optimization.

In clinical environment, Interventional X-Ray (IXR) system is used on various anatomies and for various types of the procedures. It is important to classify correctly each exam of IXR system into respective procedures and/or assign to correct anatomy. This classification enhances productivity of the system in terms of better scheduling of the Cath lab, also provides means to perform device usage/revenue forecast of the system by hospital management and focus on targeted treatment planning for a disease/anatomy.

An Approach Toward Automatic Classification of Tumor Histopathology of Non-Small Cell Lung Cancer Based on Radiomic Features.

Non-small cell lung cancer contributes toward 85% of all lung cancer burden. Tumor histology (squamous cell carcinoma, large cell carcinoma, and adenocarcinoma and "not otherwise specified") has prognostic significance, and it is therefore imperative to identify tumor histology for personalized medicine; however, biopsies are not always possible and carry significant risk of complications. Here, we have used Radiomics, which provides an exhaustive number of informative features, to aid in diagnosis and therapeutic outcome of tumor characteristics in a noninvasive manner.

Data on the cost effective surface sterilization method for C.carandas (L.) seeds and callus induction from aseptic seedling.

Surface sterilization of explant is an important and most sensitive step in plant tissue culture. Inappropriate concentrations of sterilants have lethal effect in cell division and it restricts growth and development of explant. Therefore, suitable concentration, combinations and duration of exposure of sterilant is essential to raise in vitro cultures successfully.