Characterization of Tailoring Steps of Nargenicin A1 Biosynthesis Reveals a Novel Analogue with Anticancer Activities.

Nargenicin A1() is an antibacterial macrolide with effective activity against various Gram-positive bacteria, including methicillin-resistant . Due to the promising properties of this compound in inhibiting cell proliferation, immunomodulation, and the cell protective effect, there has been significant interest in this molecule. Recently, the biosynthetic gene cluster (BGC) of was reported from and .

Bioactive molecules from Nocardia: diversity, bioactivities and biosynthesis.

Nocardia spp. are catalase positive, aerobic, and non-motile Gram-positive filamentous bacteria. Many Nocarida spp.

Production of a Novel Tetrahydroxynaphthalene (THN) Derivative from sp. CS682 by Metabolic Engineering and Its Bioactivities.

Nargenicin A1 is major secondary metabolite produced by sp. CS682, with an effective antibacterial activity against various Gram-positive bacteria. Most spp.

TP53 codon 72 polymorphism and the risk of glaucoma in a north Indian cohort: A genetic association study.

Background: The TP53 codon 72 Proline-Arginine polymorphism (TP53 P72R) is the most widely studied candidate among those evaluated for a putative association between impaired apoptosis and glaucoma. Considering the earlier findings about enhanced apoptotic potential by the Arg variant of TP53 P72R and the conflicting results about its association with glaucoma, we initiated a hospital-based case-control association study in a north Indian cohort to investigate the association of TP53 P72R with glaucoma.

Materials And Methods: We examined the status of TP53 P72R in 139 cases of primary open angle glaucoma (POAG) and in 111 cases of primary angle closure glaucoma (PACG) with respect to 218 controls using the polymerase chain reaction-restriction fragment length polymorphism method.

Isolation and identification of Acinetobacter species with special reference to antibiotic resistance.

Background: Acinetobacter is clinically important pathogen with widespread resistance to various antibiotics. We assessed the incidence of Acinetobacter infection at a tertiary care hospital, analyze their resistance pattern and identify the production of extended spectrum β-lactamases (ESBLs) and metallo β-lactamases (MBLs).

Materials And Methods: The study was conducted in tertiary care hospital, India over a period of 2 years.

Micronutrients, antioxidants, and carcinoma of the gallbladder.

Objectives: Nutrient deficiency in developing countries can be considered a significant contributory factor modifying the multistage process of carcinogenesis. Studies from different parts of the world have shown the deficiency of various micronutrients to be significantly associated with cancer. This study was undertaken to test the above hypothesis in patients with carcinoma of the gallbladder.