Emerging trends in fungal endocarditis: clinical complexity, diagnostic challenges, and therapeutic implications - a case series and literature review.

Background: Fungal infective endocarditis (IE) is a rare, yet increasingly recognised condition associated with substantial mortality rates. and are among the notable causative agents, presenting diverse clinical manifestations and complexities in diagnosis and management.

Objectives: This study was undertaken to examine the clinical profiles, diagnostic challenges, treatment modalities, and outcomes of four compelling cases involving and endocarditis.

Ni- and Co-Based MOF-Derived NiCoO Materials: As an Efficient Anode for Direct Methanol Fuel Cell Application.

Finding inexpensive and efficient anode materials is crucial for the oxidation of methanol in the direct methanol fuel cell (DMFC), which is the key electrode reaction. Herein, we report metal-organic framework (MOF)-derived CoO, NiO, and NiCoO (where = 1.5, 1, and 0.

Tuberculosis is the predominant infection in systemic sclerosis: thirty-year retrospective study of serious infections from a single centre.

To look for the spectrum of infections and the factors predisposing to infection in patients with systemic sclerosis (SSc). In this retrospective study, demographic, clinical features, details of infections, immunosuppressive therapy, and outcomes of patients with SSc attending clinics at department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India from 1990 to 2022 were captured. Multivariable-adjusted logistic regression was applied to identify independent predictors of infection.

Mycotic aneurysms: uncommon pathogens and treatment conundrums.

Mycotic aneurysms, characterized by vessel wall dilation resulting from infections including bacteria, fungi, and viruses, are a rare but severe consequence of systemic infections. The term 'mycotic' was coined by William Osler to describe the first instance of a fungal-induced infected aneurysm. These aneurysms, accounting for 0.

Prospective Approach to Deciphering the Impact of Intercellular Mitochondrial Transfer from Human Neural Stem Cells and Brain Tumor-Initiating Cells to Neighboring Astrocytes.

The communication between neural stem cells (NSCs) and surrounding astrocytes is essential for the homeostasis of the NSC niche. Intercellular mitochondrial transfer, a unique communication system that utilizes the formation of tunneling nanotubes for targeted mitochondrial transfer between donor and recipient cells, has recently been identified in a wide range of cell types. Intercellular mitochondrial transfer has also been observed between different types of cancer stem cells (CSCs) and their neighboring cells, including brain CSCs and astrocytes.

Effect and mechanism of ultrasound on acid loading in the preparation of silicon-based sulfonic solid acids.

Silicon-based sulfonic solid acids have the advantages of high catalytic activity and selectivity, easy separation from products, low equipment corrosion, and environmental protection, and sulfuric acid loading is the key to their preparation. To overcome the shortcomings of low acid loading and uneven distribution in the existing preparation methods of micron-sized silicon-based sulfonic solid acids, a method was proposed to prepare micron-sized silicon-based sulfonic solid acids using ultrasonic enhanced technology. The effect of different reaction parameters, such as time, power, and temperature of ultrasonication, sulfonation temperature and time, and sulfuric acid concentration, on acid loading in solid acid was investigated in this work.

Venetoclax-based therapy in treatment-naïve and relapsed/refractory acute myeloid leukemia.

Combining venetoclax with the hypomethylating agents azacitidine or decitabine has shown high complete response rates (60-70 %) in newly diagnosed (ND) acute myeloid leukemia (AML). However, studies addressing the efficacy of this approach in relapsed/refractory (R/R) AML remain limited. We conducted a retrospective analysis on patients treated with venetoclax-based therapy at a single institution.

Biomarker-Directed Therapy in Black and White Men With Metastatic Castration-Resistant Prostate Cancer.

Importance: Black men have higher incidence and mortality from prostate cancer. Whether precision oncology disparities affect Black men with metastatic castration-resistant prostate cancer (mCRPC) is unknown.

Objective: To compare precision medicine data and outcomes between Black and White men with mCRPC.

Retinol palmitate in management of chronic Steven-Johnson Syndrome with ocular surface keratinization.

Purpose: To study the outcomes of topical Retinol Palmitate ophthalmic solution in chronic Stevens-Johnson Syndrome with ocular surface keratinisation.

Methods: It was a comparative interventional study conducted at Rajendra Prasad Centre for Ophthalmic Sciences, Delhi, India from 2020 to 2022 evaluating outcomes of addition of topical Retinol Palmitate to conventional treatment objectively as well as subjectively from baseline up to 12 weeks.

Results: A statistically significant improvement was seen in patients who received topical Retinol palmitate at 12 weeks in terms of Schirmer-1 test(p=<0.

The international reference system for beta-particle emitting radionuclides: Validation through the pilot study CCRI(II)-P1.Co-60.

The Bureau International des Poids et Mesures (BIPM) is developing a new transfer instrument to extend its centralized services for assessing the international equivalence of radioactive standards to new radionuclides. A liquid scintillation counter using the triple/double coincidence ratio method is being studied and tested in the CCRI(II)-P1.Co-60 pilot study.

The epidemiology, clinical presentation and treatment outcomes in CNS actinomycosis: a systematic review of reported cases.

Background: CNS actinomycosis is a rare chronic suppurative infection with non-specific clinical features. Diagnosis is difficult due to its similarity to malignancy, nocardiosis and other granulomatous diseases. This systematic review aimed to evaluate the epidemiology, clinical characteristics, diagnostic modalities and treatment outcomes in CNS actinomycosis.

Treatment of complex sulfur-containing solutions in ammonia desulfurization ammonium sulfate production by ultrasonic-assisted ozone technology.

In this work, the cause of abnormal color in ammonium sulfate products formed by flue gas desulfurization is revealed by investigating the conversion relationship between different sulfur-containing ions and their behavior in a sulfuric acid medium. Both thiosulfate (SO) and sulfite (SO ＆ HSO) impurities affect the quality of ammonium sulfate. The SO is the main reason for the yellowing of the product due to the formation of sulfur impurities in concentrated sulfuric acid.

Functional Outcomes After Surgical Resection of Tongue Cancer; A Comparative Study Between Primary Closure, Secondary Intention Healing and Flap Reconstruction.

The purpose of the study was to assess and compare the quality of speech and swallowing between three reconstruction options (-group A, group B and group C), in small to moderate sized onco-surgical defects of oral tongue. 47 patients fulfilled the eligibility criteria during the study period, of which, 15 belonged to group A, 16 belonged to group B, 16 were in group C. Speech and swallowing assessment was done using Speech Intelligibility Assessment score and MD Anderson Dysphagia Inventory, respectively.

Neutropenic Enterocolitis: A Rare Complication of Sacituzumab Govitecan.

Neutropenic enterocolitis (NE) is a rare form of inflammatory colitis seen in severely neutropenic patients. Patients with NE typically have severe neutropenia (absolute neutrophil count [ANC] <500/mm) in the setting of exposure to cytotoxic chemotherapy. Taxanes have traditionally been associated with NE, but there has been a growing amount of literature, linking a variety of other chemotherapeutic agents.

Ultrasonic-assisted ozone degradation of organic pollutants in industrial sulfuric acid.

In this work, a combination of ozone (O) and ultrasound (US) has been firstly used to decolorize black concentrated sulfuric acid with high organic content. The effect of different reaction factors on the transparency, extent of decolorization, HSO mass fraction, and organic pollutants removal is studied. In addition, the systematic interaction between ultrasound and ozone on the decolorization process is reviewed through comparative experiments of O, US and US/O.

Activity measurement of mixed complex radionuclide like Eu with different methods.

Eu has been standardized by three independent 4π β-γ coincidence counting systems with beta detectors as proportional counter, plastic scintillator and liquid scintillator along with the CIEMAT/NIST method. The average activity concentration by primary methods was linked to key comparison reference value (KCRV) by comparing it with that of 4π γ ionization chamber (GIC) whose calibration factor was determined from the KCRV (BIPM.RI(II)-K1.

Kinetics of Ni, V and Fe Leaching from a Spent Catalyst in Microwave-Assisted Acid Activation Process.

Ni, V and Fe are the main contaminant metals that lead to the deactivation of the spent fluid catalytic cracking (SFCC) catalyst. In this work, the properties and distribution of Ni, V and Fe in the SFCC catalyst are investigated by employing EPMA-EDX, SEM and XPS techniques. The kinetics of Ni, V, Fe and Al leaching in organic and inorganic acids are studied under microwave heating.

Gender and genetic factors impacting COVID-19 severity.

COVID-19 pandemic is a cause of global concern and is impacting lives and economy globally. Infection due to SARS-CoV-2 leads to varied clinical manifestations, which can vary from asymptomatic to severe acute respiratory syndrome and death. The clinical features are proposed to depend upon various host factors, namely, gender and genetic factors.