General model to describe the structure and dynamic balance between different human serum lipoproteins and its practical application.

Background: Many dangerous diseases are associated with changes in the concentration of blood lipoproteins (LPs). Thus a fast and accurate method is needed to determine the composition of lipoprotein fractions in human serum.

Material/methods: A comparison of 30 parameters characterizing different LPs in serum from 120 healthy donors and 102 multiple sclerosis patients was carried out using a unique algorithm developed to determine the concentrations of all the main lipids and apolipoproteins in each LP fraction and subfraction.