Publications by authors named "Ravikumar M"

Article Synopsis
  • Epilepsy affects about 70 million people globally, with roughly 30% of patients not responding to current antiepileptic drugs, underscoring the need for more effective treatments.
  • The study investigates Necrostatin-1 (Nec-1), a selective RIPK1 inhibitor, for its potential anticonvulsant effects in zebrafish larvae with PTZ-induced seizures.
  • Results showed that Nec-1 helped restore normal behavior, decreased inflammatory cytokine levels, and improved GABA receptor expression, indicating its potential as a new treatment approach for epilepsy.
View Article and Find Full Text PDF
Article Synopsis
  • Snakebite envenoming (SBE) causes over 500,000 deaths or serious injuries annually, and a phase II clinical trial was conducted to evaluate the safety and efficacy of varespladib methyl, an oral treatment, in patients bitten by venomous snakes.
  • The trial, which was double-blind and placebo-controlled, enrolled patients in emergency departments in the USA and India, assessing changes in severity of snakebite symptoms using the Snakebite Severity Score (SSS) after treatment.
  • Results indicated no significant difference in SSS improvement between the varespladib and placebo groups overall, but early treatment (within 5 hours of the bite) showed potential benefits in illness severity and recovery outcomes.
View Article and Find Full Text PDF

Given the rapid growth of the nuclear sector, effective treatment of radioactive iodine is critical. Herein, we report the synthesis and the iodine adsorption properties of croconic acid (CTPB) and squaric acid (STPB) containing π-conjugated novel zwitterionic conjugated porous polymers (CPPs). The CPPs have been synthesized through a condensation reaction of tris(4-aminophenyl)benzene with croconic acid or squaric acid in high yields (~95 %).

View Article and Find Full Text PDF

Introduction: Quality sleep is essential to our health and well-being. Summertime temperatures in the bedrooms of homes in temperate climates are increasing, especially in city apartments. There is very little empirical evidence of the effect of temperature on sleep when people are sleeping in their own bedroom.

View Article and Find Full Text PDF

Cultivated meat offers an avenue to feed a growing population and reduce environmental burdens associated with conventional meat production. In this Science & Society paper, we outline challenges the industry is facing in obtaining robust cell lines for the development of cultivated meat products. Through an industry survey, several knowledge gaps in cell biology were identified and are presented as research opportunities here.

View Article and Find Full Text PDF

Arteria lusoria (AL) is a rare embryological variant that may have variable presentation ranging from asymptomatic to respiratory, abdominal, or both. Increasing incidence of radial access for coronary angiogram may lead to the incidental diagnosis of AL. Knowledge about this anatomical variation is essential for cardiologists, interventional radiologists, otorhinolaryngologists, cardiothoracic surgeons, and primary physicians.

View Article and Find Full Text PDF

Water scarcity is a pressing issue experienced in numerous countries and is expected to become increasingly critical in the future. Anthropogenic activities such as mining, agriculture, industries, and domestic waste discharge toxic contaminants into natural water bodies, causing pollution. Addressing these environmental crises requires tackling the challenge of removing pollutants from water.

View Article and Find Full Text PDF

Biodiesel represents a biodegradable, environmentally friendly, and renewable alternative to fossil fuels. Despite more than three decades of research, significant obstacles still hinder the widespread production of biodiesel. This current review elucidates both the potential and the existing challenges associated with homogeneous and heterogeneous catalysts in catalyzing biodiesel production, with a particular focus on alkali analogues, alkaline earth metal oxides, and titania-based catalysts.

View Article and Find Full Text PDF

The carbon dioxide (CO) crisis is one of the world's most urgent issues. Meeting the worldwide targets set for CO capture and storage (CCS) is crucial. Because it may significantly reduce energy consumption compared to traditional amine-based adsorption capture, adsorption dependant CO capture is regarded as one of the most hopeful techniques in this paradigm.

View Article and Find Full Text PDF

This study demonstrates the synthesis of titanium oxynitride (TiON) via a controlled step-annealing of commercial titanium nitride (TiN) powders under normal ambience. The structure of the formed TiON system is confirmed via XRD, Rietveld refinements, XPS, Raman, and HRTEM analysis. A distinct plasmonic band corresponding to TiN is observed in the absorption spectrum of TiON, indicating that the surface plasmonic resonance (SPR) property of TiN is being inherited in the resulting TiON system.

View Article and Find Full Text PDF

Vascular endothelial growth factor (VEGF) signals cell survival, cell migration, osteogenesis, cell proliferation, angiogenesis, and vascular permeability by binding to VEGF receptor 2 (VEGFR-2). Osteosarcoma is the most common primary bone cancer, majorly affects young adults. Activation of VEGFR-2 signaling is a therapeutic target for osteosarcoma.

View Article and Find Full Text PDF

Most of the persons with noise exposure will have clinically normal hearing threshold while experiencing reduced speech comprehension. The motive of this study is to assess the impact of occupational noise on the encoding of speech stimuli in the auditory system in the auto-rickshaw drivers and compare the auditory brainstem responses (ABR) using speech stimuli with that of controls. The study was done in experimental design, where speech evoked ABR was measured in 21 auto-drivers who were continuously exposed to higher levels of occupational noise, and they were compared to the results of 37 individuals who were not exposed to noise.

View Article and Find Full Text PDF

Background And Objective: Radiation induced toxicities in heart and lungs are diminishes the survival rate of cancer patients. The purpose of this study is to evaluate the dosimetric parameters of hybrid plans for chest wall irradiation of left breast carcinoma patients using Monaco treatment planning system and compare with the volumetric-modulated arc therapy (VMAT) treatment plans. Materials and Methods: Fifteen carcinoma left breast patients were randomly selected to evaluate the advantage of hybrid plan over VMAT.

View Article and Find Full Text PDF

Background: Alzheimer's disease (AD) is an age-dependent neurodegenerative disease with progressive cognition and memory loss, insomnia, and other abnormal behavioral changes. Amongst various hypotheses for AD pathophysiology, occupational stress-induced Alzheimer's has recently been reported in many AD cases.

Objective: Studies pertaining to the same suggest that stress leads to insomnia or sleep disruption, which further leads to neuroinflammation due to oxidative stress, both of which are major harbingers of AD.

View Article and Find Full Text PDF
Article Synopsis
  • Chronic Gulf War Illness (GWI) is linked to cognitive and mood issues, oxidative stress, and neuroinflammation, creating significant health challenges for veterans.
  • The study explored the use of low-dose, oral polymer nanoparticle-encapsulated curcumin (nCUR) to enhance brain function in a rat model of GWI, showing promising results in reducing brain dysfunction.
  • Treatment with nCUR led to improved cognitive and mood functions, enhanced mitochondrial performance, reduced neuroinflammation, and promoted neurogenesis, suggesting potential benefits for veterans suffering from GWI.
View Article and Find Full Text PDF

Therapies using mesenchymal stromal cells (MSCs) to treat immune and inflammatory conditions are now at an exciting stage of development, with many MSC-based products progressing to phase II and III clinical trials. However, a major bottleneck in the clinical translation of allogeneic MSC therapies is the variable immunomodulatory properties of MSC products due to differences in their tissue source, donor heterogeneity and processes involved in manufacturing and banking. This variable functionality of MSC products likely contributes to the substantial inconsistency observed in the clinical outcomes of phase III trials of MSC therapies; several trials have failed to reach the primary efficacy endpoint.

View Article and Find Full Text PDF

In 1967, Dr. René Favaloro introduced the use of reversed greater saphenous vein graft for coronary artery bypass grafting, since then a lot of efforts were made to improve the venous graft patency rate. We introduce a novel double cobra head technique of distal coronary anastomosis for better distal runoff.

View Article and Find Full Text PDF

Background: Frequency tuning of ocular vestibular evoked myogenic potential (oVEMP) refers to the frequency of tone burst that produces the largest amplitude oVEMP. There is an ever-growing pool of published studies that found the frequency tuning of oVEMP distinctly different in Ménière's disease than the age-matched controls and benign paroxysmal positional vertigo. However, recording oVEMP in response to many frequencies makes an already lengthy vestibular test battery even more cumbersome and time-consuming.

View Article and Find Full Text PDF

In the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, the physician finds difficulty in differentiating the symptoms due to cardiac disease from that of SARS-CoV-2. We would like to present one such mystified situation (hemosiderosis versus SARS-CoV-2 pneumonia) we encountered.

View Article and Find Full Text PDF

Dextrocardia with situs inversus is a rare congenital anomaly in which the heart and the abdominal organs orient themselves in a mirror-image reversal of the normal anatomy. Coronary artery disease incidence is similar to that of the normal population. Performing coronary artery bypass grafting in this subset of the population poses few difficulties.

View Article and Find Full Text PDF

Human mesenchymal stem/stromal cell (hMSC)-based cell therapies are promising for treating a variety of diseases. The unique immunomodulatory properties of hMSCs have extended their therapeutic potential beyond tissue regeneration. However, extensive pre-clinical culture expansion inevitably drives cells toward replicative "aging" and a consequent decline in quality.

View Article and Find Full Text PDF
Article Synopsis
  • Plant type III polyketide synthases (PKSs) play key roles in banana growth, development, and defense by producing various polyketide compounds for specialized metabolic pathways (SMPs).
  • A comparative analysis of the A (Musa acuminata) and B (Musa balbisiana) banana genomes identified multiple PKS types and highlighted significant duplication events that expanded the PKS family.
  • Expression profiling of selected PKSs in response to jasmonic acid and salicylic acid treatments revealed that certain PKSs showed high expression levels, indicating their potential roles in producing flavonoids and other compounds relevant for banana defense mechanisms.
View Article and Find Full Text PDF

Heparan sulfate proteoglycans (HSPGs) are an evolutionarily ancient subclass of glycoproteins with exquisite structural complexity. They are ubiquitously expressed across tissues and have been found to exert a multitude of effects on cell behavior and the surrounding microenvironment. Evidence has shown that heterogeneity in HSPG composition is crucial to its functions as an essential scaffolding component in the extracellular matrix as well as a vital cell surface signaling co-receptor.

View Article and Find Full Text PDF