Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity.

Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles, including the endoplasmic reticulum. This communication is important in thermogenic adipocytes to increase the energy expenditure that controls body temperature and weight. However, the regulatory mechanisms of OMM protein insertion are poorly understood.

The modification and adoption of biolubricants as alternatives in the automotive industry.

Lubricants are pivotal in mitigating friction and wear between surfaces, ensuring seamless movement of solid objects. However, the predominant use of petroleum-based lubricants in the automotive and industrial ssectors raises substantial concerns for future energy security. The exploration of vegetable oils as an alternative lubricant in the automotive industry was motivated by the depletion of fossil fuels and escalating environmental concerns.

Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies.

Influenza has been responsible for multiple global pandemics and seasonal epidemics and claimed millions of lives. The imminent threat of a panzootic outbreak of avian influenza H5N1 virus underscores the urgent need for pandemic preparedness and effective countermeasures, including monoclonal antibodies (mAbs). Here, we characterize human mAbs that target the highly conserved catalytic site of viral neuraminidase (NA), termed NCS mAbs, and the molecular basis of their broad specificity.

Human umbilical cord mesenchymal stem cells toxicity and allergy effects: In vivo assessment.

Objective: Human umbilical cord mesenchymal stem cells (hUCMSCs) hold significant promise across various clinical applications. Therefore, regulatory requirements necessitate a thorough investigation of the hUCMSCs safety before clinical trials and potential allergic reactions after transplantation.

Methods: Abnormal toxicity test employed mice and guinea pigs dosed daily at 0.

Turbulent characteristics of momentum flux in the marine atmospheric boundary layer of North Bay of Bengal.

We use a 16-month-long, 20 Hz wind data from a mooring deployed in the Bay of Bengal (BoB) to study the characteristics of turbulent wind stress ( events in the marine atmospheric boundary layer (MABL). Quadrant analysis of the motion-corrected and suggests that sweep and ejections, representing downward stress transfer into the ocean, dominate the (~ 140%). In comparison, outward and inward interactions representing an upward stress transfer into the atmosphere provide the counter-contribution (~ 40%).

Carbon dioxide capture, sequestration, and utilization models for carbon management and transformation.

The elevated level of carbon dioxide in the atmosphere has become a pressing concern for environmental health due to its contribution to climate change and global warming. Simultaneously, the energy crisis is a significant issue for both developed and developing nations. In response to these challenges, carbon capture, sequestration, and utilization (CCSU) have emerged as promising solutions within the carbon-neutral bioenergy sector.

Comprehensive insights into oral squamous cell carcinoma: Diagnosis, pathogenesis, and therapeutic advances.

Oral squamous cell carcinoma (OSCC) is considered the most common type of head and neck squamous cell carcinoma (HNSCC) as it holds 90 % of HNSCC cases that arise from multiple locations in the oral cavity. The last three decades witnessed little progress in the diagnosis and treatment of OSCC the aggressive tumor. However, in-depth knowledge about OSCC's pathogenesis, staging & grading, hallmarks, and causative factors is a prime requirement in advanced diagnosis and treatment for OSCC patients.

Isoptericola haloaureus sp. nov., a dimorphic actinobacterium isolated from mangrove sediments of southeast India, implicating biosaline agricultural significance through nitrogen fixation and salt tolerance genes.

Strain MP-1014, an obligate halophilic actinobacterium, was isolated from the mangrove soil of Thandavarayancholanganpettai, Tamil Nadu, India. A polyphasic approach was utilized to explore its phylogenetic position completely. The isolate was Gram-positive, filamentous, non-motile, and coccoid in older cultures.

Tide of change: Urgency of a national marine litter policy in India.

The rise of plastics in the 20th century revolutionized modern life but inadvertently exacerbated the marine litter crisis. The proliferation of wastes such as single-use plastics has escalated pollution along the coastline, demanding coordinated, decisive, and unified action. While the absence of specific national marine litter policies is concerning, there is growing recognition of urgency to address this issue.

Knowledge and practice of breastfeeding among lactating mothers in AIIMS, Bhubaneswar - A hospital-based cross-sectional study.

Background: 44% of infants under 6 months of age worldwide are only adequately breastfed. It is also found that only 41.6% of women breastfeed their child within one hour of birth and less than 50% of women continue breastfeeding up to 2 years.

Chimeric antigen receptor-natural killer cell therapy: current advancements and strategies to overcome challenges.

Chimeric antigen receptor-natural killer (CAR-NK) cell therapy is a novel immunotherapy targeting cancer cells via the generation of chimeric antigen receptors on NK cells which recognize specific cancer antigens. CAR-NK cell therapy is gaining attention nowadays owing to the ability of CAR-NK cells to release potent cytotoxicity against cancer cells without side effects such as cytokine release syndrome (CRS), neurotoxicity and graft-versus-host disease (GvHD). CAR-NK cells do not require antigen priming, thus enabling them to be used as "off-the-shelf" therapy.

A case series on safety and tolerability of human umbilical cord-derived mesenchymal stem cells on patients in Malaysia.

Umbilical cord-derived mesenchymal stem cells for regenerative therapy are a promising treatment option for chronic illnesses. Umbilical cord-derived mesenchymal stem cells offer several advantages over other sources, which makes them an attractive option in tissue repair and regeneration. This clinical study describes a 1-year follow-up on the safety and tolerance of umbilical cord-derived mesenchymal stem cell therapy on nine patients in Malaysia.

Genetic dependencies associated with transcription factor activities in human cancer cell lines.

Transcription factors (TFs) are important mediators of aberrant transcriptional programs in cancer cells. In this study, we focus on TF activity (TFa) as a biomarker for cell-line-selective anti-proliferative effects, in that high TFa predicts sensitivity to loss of function of a given gene (i.e.

Applications of CRISPR-Cas9 for advancing precision medicine in oncology: from target discovery to disease modeling.

The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) (CRISPR/Cas9) system is a powerful tool that enables precise and efficient gene manipulation. In a relatively short time, CRISPR has risen to become the preferred gene-editing system due to its high efficiency, simplicity, and programmability at low costs. Furthermore, in the recent years, the CRISPR toolkit has been rapidly expanding, and the emerging advancements have shown tremendous potential in uncovering molecular mechanisms and new therapeutic strategies for human diseases.

Functional characterization of Alzheimer's disease genetic variants in microglia.

Candidate cis-regulatory elements (cCREs) in microglia demonstrate the most substantial enrichment for Alzheimer's disease (AD) heritability compared to other brain cell types. However, whether and how these genome-wide association studies (GWAS) variants contribute to AD remain elusive. Here we prioritize 308 previously unreported AD risk variants at 181 cCREs by integrating genetic information with microglia-specific 3D epigenome annotation.

Comprehensive review on ideas, designs and current techniques in solar dryer for food applications.

Due to the expansion of residents, the consumption of non-renewable energy increased enormously, thus indirectly increasing pollution and affecting the surroundings. To reduce pollutions in the surroundings, it is recommended to choose non-conventional energy sources. By satisfying this, we can probably decrease the non-renewable sources of energy, by consuming the solar power in day-to-day life in the application of food drying process.

Marathi translation, linguistic validation, and cross-cultural adaptation of M.D. Anderson dysphagia inventory in patients of head and neck squamous cell cancer.

Background: Self-reported treatment outcome is a better way to measure patient's quality of life (QOL). This study was undertaken to translate dysphagia-specific QOL questionnaire M. D.

Environment and economic analysis of reverse supply chain scenarios for remanufacturing using discrete-event simulation approach.

The study covers the concepts involved in reverse supply chain modeling using the case of a manufacturing company. The purpose of this study is to build a sustainable reverse supply chain model for resource conservation through remanufacturing of stator shafts by using a discrete-event simulation approach. The simulation studies in the reverse supply chain have taken up cases of either plastic or electronic waste remanufacturing, while very limited studies deal with simulation of sustainable reverse supply chains using a manufacturing industry case study from international customers.

Subjective and perceptive assessment of speech/voice and swallowing function before and after radiation therapy in patients of head-and-neck squamous cell cancer.

Aim: To prospectively assess subjective and perceptive speech/voice and swallowing function before and after radiation therapy (RT) in patients of head-and-neck squamous cell cancer (HNSCC).

Materials And Methods: The study cohort comprised eligible consecutive HNSCC patients planned for curative RT from April 2018 to July 2018 who consented for the study. Prospective evaluation of speech/voice and swallowing function was done before and after RT.

Investigations on the microstructure and properties of yttria and silicon carbide reinforced aluminium composites.

Powder Metallurgy (PM) was used to synthesize SiC (0, 5, 10, 15 & 20 wt%) and 1 wt% Yttria (YO) reinforced aluminium (Al) metal matrix composites. The Al-SiC-YO hybrid composites samples were prepared for density (ρ), hardness (VHN), mechanical, tribological, and microstructural studies in accordance with ASTM standards. SEM images revealed an even spreading of SiC particles throughout the Al matrix and composition was verified by the characterization techniques.

Quantifying the role of antecedent Southwestern Indian Ocean capacitance on the summer monsoon rainfall variability over homogeneous regions of India.

The role of ocean variability is at a focal point in improving the weather and climate forecasts at different spatial and temporal scales. We study the effect of antecedent southwestern Indian Ocean mean sea level anomaly (MSLA) and sea surface temperature anomalies (SSTA) as a proxy to upper ocean heat capacitance on all India summer monsoon rainfall (AISMR) during 1993-2019. SSTA and MSLA over the southwestern Indian Ocean (SWIO) have been influenced by El Niño-Southern Oscillation (ENSO), the impact of ENSO-induced SWIO variability was low on rainfall variability over several homogeneous regions.

Fabrication and wear behaviour of Mg-3wt.%Al- wt. % SiC composites.

In this work, Silicon Carbide (SiC) reinforced Mg/3Al matrix composite was developed via powder metallurgy (PM) method. Friction coefficient (COF) and wear rate (WR) of the composite was studied using Pin on disc wear tester. Scanning Electron Microscope (SEM) was used to investigate the microstructure of sintered samples.

Synthesis, Characterization, Cytotoxicity Analysis and Evaluation of Novel Heterocyclic Derivatives of Benzamidine against Periodontal Disease Triggering Bacteria.

Periodontal disease (PD) is multifactorial oral disease that damages tooth-supporting tissue. PD treatment includes proper oral hygiene, deep cleaning, antibiotics therapy, and surgery. Despite the availability of basic treatments, some of these are rendered undesirable in PD treatment due to side effects and expense.