ePRO symptom follow-up of colorectal cancer patients receiving oxaliplatin-based adjuvant chemotherapy is feasible and enhances the quality of patient care: a prospective multicenter study.

Purpose: Electronic (e) patient-reported outcomes (PROs) have been shown to improve the quality of life and survival in chemotherapy treated advanced cancer patients. We hypothesized that multidimensional ePRO centered approach could improve symptom management, streamline patient flow, and optimize the use of healthcare resources.

Methods: In this multicenter trial (NCT04081558), colorectal cancer (CRC) patients receiving oxaliplatin-based chemotherapy as adjuvant or in the first- or second-line setting in advanced disease were included in the prospective ePRO cohort, while a comparative retrospective cohort was collected from the same institutes.

An micro-CT assessment of bioactive restorative materials interfacial adaptation to dentin.

Background: The background of this study was to improve the longevity of a restoration and optimal adaptation of restorative material to the prepared cavity walls is crucial. The study aimed to evaluate the interfacial adaptation of Activa, Micron, and Predicta bulk bioactive restorative materials to coronal dentin using micro-computed tomography (CT) analysis.

Materials And Methods: In this micro-CT assessment study, Class II mesio- and disto-occlusal cavities were prepared on 60 extracted human mandibular molar teeth.

An In-vitro Fracture Strength Assessment of Endodontically Treated Teeth with Different Root-End Materials.

Objective: To assess and compare the fracture strength of endodontically treated teeth when the retrograde preparations were restored either with Biodentine or Endosequence BC RRM Fast set putty or Geristore.

Methods: One hundred and twenty human mandibular premolars were used and allocated randomly into five groups (n=24 each). Following conventional root canal treatment, and apical root resection, retrograde cavities of 3 mm were prepared using ultrasonic tips.

Relationship between the Depth of Penetration and Fracture Resistance of Various Sealers: A Comparative Study.

Aim: The aim of this study was to estimate the penetration depth and fracture resistance of three different sealers and to verify the relationship between the penetration depth and fracture resistance.

Materials And Methods: Sixty single-rooted teeth were selected and root canal preparation was done. After the instrumentation, the teeth were divided into three groups of 20 each.

Preemptive screening of DPYD as part of clinical practice: high prevalence of a novel exon 4 deletion in the Finnish population.

Capecitabine is a fluoropyrimidine that is widely used as a cancer drug for the treatment of patients with a variety of cancers. Unfortunately, early onset, severe or life-threatening toxicity is observed in 19-32% of patients treated with capecitabine and 5FU. Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme in the degradation of 5FU and a DPD deficiency has been shown to be a major determinant of severe fluoropyrimidine-associated toxicity.

Microtensile Bond Strength Evaluation of Composite Resin to Discolored Dentin After Amalgam Removal.

Background To obtain prolonged clinical success with composite restorations, better bonding of resin to the tooth substrate is crucial. Aim The study was aimed to evaluate the microtensile bond strength (µTBS) of bulk-fill composite resin restorations when bonded to a cavity previously restored with amalgam, comparing with that of freshly prepared dentin. Materials and method Mesio-occlusal cavity preparations were done on 80 extracted human mandibular molars with a buccolingual width of 4 mm and a 1.

Effect of pretreatment medication on postendodontic pain: A double-blind, placebo-controlled study.

Background: Posttreatment endodontic pain has been reported in 25%-40% of all endodontic patients. Effective management of endodontic pain represents a continuing challenge.

Aim: To evaluate and compare the efficacy of preoperative single dose of nonsteroidal anti-inflammatory drug, piroxicam (20 mg), with two types of corticosteroid drugs - dexamethasone (4 mg) or deflazacort (30 mg) - for the prevention and control of postendodontic pain.

Micro-computed tomographic evaluation of dentinal defects after root canal preparation with hyflex edm and vortex blue rotary systems.

Background: To evaluate the incidence of dentinal microcracks formation after root canal shaping procedures with HyFlex EDM and Vortex Blue rotary systems comparing with that of hand instrumentation using micro-computed tomography.

Material And Methods: Mandibular first molar teeth (n=60) having 50 to 200mesial root curvature were scanned using high resolution micro-CT imaging before root canal preparation to identify the presence of dentinal defects. Post-instrumentation cross-sectional images were taken and increased number and type of root defects were assessed and recorded.

Microtensile bond strength of bulk-fill restorative composites to dentin.

Background: To facilitate the easier placement of direct resin composite in deeper cavities, bulk fill composites have been introduced. The Mechanical stability of fillings in stress bearing areas restored with bulk-fill resin composites is still open to question, since long term clinical studies are not available so far. Thus, the objective of the study was to evaluate and compare the microtensile bond strength of three bulk-fill restorative composites with a nanohybrid composite.