Publications by authors named "Ravi Vazirani"

We present the case of an 80-year-old female with acute pulmonary edema and a dual chamber pacemaker with intermittent short AV delays in the surface ECG after blocked premature atrial contractions (PACs). The behavior was consistent with the programmed Window of Atrial Rate Acceleration Detection (WARAD) and did not require further parameter modifications. As most cardiologists and emergency department physicians are not familiar with brand-specific algorithms, we believe that this case report will make these noncompetitive atrial pacing algorithms more accessible to non-cardiologists.

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Article Synopsis
  • A study analyzed 412 patients with Takotsubo syndrome who experienced cardiogenic shock, revealing that 17.2% of these patients were men.
  • Men were generally older, had higher smoking rates, and showed worse heart function and longer hospital stays compared to women.
  • Despite differences in health conditions during hospitalization, sex did not significantly affect short- or long-term mortality rates in these patients.
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Background: Cardiogenic shock (CS) complicates Takotsubo syndrome (TTS), significantly affecting patient outcomes. Since avoiding catecholamines, particularly inotropic agents, is recommended in TTS, temporary mechanical circulatory support (MCS) shows promise as a bridge to recovery. However, there is no prospective data on its use in TTS.

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Background: Takotsubo syndrome (TTS) is a form of transient left ventricular (LV) dysfunction that usually resolves within days to weeks.

Objectives: We aimed to assess the predictors and prognostic impact of time-to-LV recovery after TTS.

Methods: Prospective serial imaging data from the nationwide, multicenter RETAKO (REgistry on TAKOtsubo Syndrome) were comprehensively reviewed to assess the timing of LV recovery.

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  • In patients with ischemic heart disease, coronary microvascular dysfunction is linked to cardiovascular risk factors and negative health outcomes, but less is known about healthy individuals.
  • This study aimed to examine how cardiovascular risk factors and early signs of atherosclerosis affect coronary microvascular function in middle-aged, asymptomatic individuals, using methods like cardiac MRI and vascular ultrasound.
  • Results showed that higher levels of metabolic syndrome components and diabetes are associated with reduced coronary blood flow and that better microvascular function is linked to less progression of atherosclerosis over three years.
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Background: F-Fluorodeoxyglucose (F-FDG) positron emission tomography (PET)/magnetic resonance (MR) can identify inflammation and fibrosis, which are high-risk features in cardiac sarcoidosis.

Objective: The purpose of this study was to evaluate whether the involvement of certain myocardial segments is associated with higher risk compared to others.

Methods: One hundred twenty-four patients with suspected clinical sarcoidosis underwent F-FDG-PET/MR.

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Background: Patients with Takotsubo syndrome (TTS) who develop cardiogenic shock may present with left ventricular outflow tract obstruction (LVOTO). The prognosis and treatment of this population have not been defined in previous studies. The aim of this study is to describe the clinical presentation, management, evolution and prognosis of a subgroup of patients with TTS and cardiogenic shock according to whether they present with LVOTO or not.

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  • * Researchers analyzed data from the HOPE-2 registry, examining 2382 patients discharged alive and tracking their mortality and long-term COVID-19 symptoms.
  • * Findings reveal that patients with elevated troponin levels face higher mortality rates and are more likely to experience lasting cardiovascular issues, such as fatigue and dyspnea, after discharge.
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Introduction: Data on the association between kidney function and Takotsubo syndrome (TTS) outcomes are scarce and conflictive.

Objective: To assess the impact of chronic kidney disease (CKD) and acute renal failure (ARF) in patients with TTS.

Material And Methods: Patients from the prospective nation-wide (RETAKO) registry were included and divided into quartiles of maximum creatinine (Cr) level during hospitalization.

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Takotsubo syndrome (TTS) in the pediatric population is an infrequent but relevant cause of morbidity and mortality, with limited studies addressing its clinical course and prognosis. We aimed to analyze the clinical features and prognosis of pediatric TTS in a nation-wide multicenter registry and considering the published literature. We included a total of 54 patients from 4 different hospitals in Spain, as well as pediatric TTS patients from the published literature.

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Background: Cardiogenic shock (CS) is a significant complication of Takotsubo syndrome (TTS), contributing to heightened mortality and morbidity. Despite this, the Society for Cardiovascular Angiography and Interventions (SCAI) staging system for CS severity lacks validation in patients with TTS and CS. This study aimed to characterize a patient cohort with TTS using the SCAI staging system and assess its utility in cases of TTS complicated by CS.

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Article Synopsis
  • - Takotsubo syndrome (TTS) during the peripartum period is a significant health issue, with unclear prognosis compared to the general TTS population, prompting a study utilizing a nationwide registry.
  • - Analysis showed that peripartum TTS patients commonly experience atypical symptoms like dyspnea, have different echocardiographic findings, and less ST-segment elevation than other TTS patients.
  • - Despite presenting with higher Killip status upon admission, peripartum TTS patients often have good long-term prognoses, even though their conditions are mainly secondary and linked to physical stressors.
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Objective: Experimental evidence suggests that metabolic syndrome (MetS) is associated with changes in cardiac metabolism. Whether this association occurs in humans is unknown.

Research Design And Methods: 821 asymptomatic individuals from the Progression of Early Subclinical Atherosclerosis (PESA) study (50.

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Background: Alzheimer's Disease (AD) can cause degeneration in the retina and optic nerve either directly, as a result of amyloid beta deposits, or secondarily, as a result of the degradation of the visual cortex. These effects raise the possibility that tracking ophthalmologic changes in the retina can be used to assess neurodegeneration in AD. This study aimed to detect retinal changes and associated functional changes in three groups of patients consisting of AD patients with mild disease, AD patients with moderate disease and healthy controls by using non-invasive psychophysical ophthalmological tests and optical coherence tomography (OCT).

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