Publications by authors named "Ravi Talati"
The evolving treatment landscape for children with sickle cell disease.
Lancet Child Adolesc Health
November 2023
Sickle cell disease is the most common inherited pathological haemoglobinopathy. Over the past 30 years, disease-related morbidity and mortality have improved in high-income countries due to advances in preventive care and treatments. Established disease-modifying therapies, such as hydroxyurea (hydrocarbamide), are continuing to have an important role in the treatment of sickle cell disease, and newer agents also show promise.
View Article and Find Full Text PDFAdolescent and young adult (AYA) patients (15-39 years old) with acute lymphoblastic leukemia (ALL) have less favorable outcomes and higher treatment-related mortality as compared with older children with ALL. Minimal data exist regarding how well AYA patients tolerate the intensity of chemotherapy at doses and regimens designed for children, and the toxicities suffered by this population at children's hospitals have not been thoroughly characterized. Pediatric Health Information Systems database was queried to analyze health care outcomes in pediatric (ages 10-14) and AYA patients (ages 15-39) with ALL hospitalized between January 1999 and December 2014.
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- Sickle cell disease (SCD) affects over 100,000 people in the USA and millions globally, with hydroxyurea being the main treatment to improve patient outcomes.
- Due to individual differences in drug response, the traditional method of starting hydroxyurea at a standard dose often leads to inadequate treatment for many patients.
- The Hydroxyurea Optimization through Precision Study (HOPS) is a multi-center trial aimed at comparing standard dosing to a personalized, pharmacokinetics (PK)-guided approach to determine which method works better for children with SCD.
Lymphoid interstitial pneumonia (LIP) is a rare disease characterized by benign reactive polyclonal proliferation of bronchus-associated lymphoid tissue after exposure to inhaled or circulating antigen(s), leading to a disease symptomatology similar to idiopathic interstitial pneumonia. Its association with diseases that are caused due to immune dysregulation (autoimmune diseases, congenital/acquired immunodeficiency, and allogeneic bone marrow transplant) and response to immunomodulatory/suppressive medications suggests an immunologic pathophysiology. Although LIP has been reported in association with lymphoproliferative diseases like Castleman disease, it has never been described in patients with leukemia.
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- Pediatric injuries from motor vehicle accidents are a serious public health issue in Delaware, particularly in areas with specific demographic characteristics.
- Researchers utilized GIS mapping software to analyze data from 2002 to 2012 from the Delaware State Trauma Registry, focusing on children under 18 who were treated for such injuries.
- The findings revealed that urban and economically disadvantaged areas, especially Wilmington, experienced the highest rates of pedestrian injuries, with notable correlations to low income, low education levels, and higher percentages of minority populations.
Previous experiments have demonstrated that the rat dorsomedial striatum is one brain area that plays a crucial role in learning when conditions require a shift in strategies. Further evidence indicates that muscarinic cholinergic receptors in this brain area support adaptations in behavioral responses. Unknown is whether specific muscarinic receptor subtypes in the dorsomedial striatum contribute to a flexible shift in response patterns.
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